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- Which of the following voltages would most likely be measured during the relative refractory period? +30 mV 0 mV -45 mV -80 mvAssume presynaptic excitatory neuron A terminates on a postsynaptic cell near the axon hillock and presynaptic excitatory neuron B terminates on the same postsynaptic cell on a dendrite located on the side of the cell body opposite the axon hillock. Explain why rapid firing of presynaptic neuron A could bring the postsynaptic neuron to threshold through temporal summation, thus initiating an action potential, whereas firing of presynaptic neuron B at the same frequency and the same magnitude of EPSPs may not bring the postsynaptic neuron to threshold.Ordinarily, a neuron’s trigger zone is activated before any other part ofan axon, so a wave of action potentials occurs as sodium channelsopen in the direction of the synaptic terminal. What would happen ifyou artificially stimulated an axon to reach threshold potential midwayalong its length rather than at the trigger zone?a. Action potentials would occur in the direction of the synapticterminal.b. No action potentials would occur.c. Action potentials would occur in the direction of the trigger zone.d. Both a and c are correct.
- A change in the voltage across a neuron’s plasma membranethat makes the neuron less likely to fire an action potential isa. a change that makes the resting potential less negative.b. an excitatory postsynaptic potential.c. an inhibitory postsynaptic potential.d. a change that lowers the threshold.If an axon ([Na+]in = 200 mM) is bathed in solution consisting of [Na+]out = 10 mM, will there be an action potential if a supra-threshold stimulus (changed Vm to -20 mV with opening of Na channels) is injected into the axon?If the plasma membrane of an electrically excitable cellwere depolarized to threshold in the center of the axon orsarcolemma, would the action potential be propagated inonly one direction? Why or why not?
- What effect would you expect an antagonist that targets the voltage sensing domain of perisynaptic calcium channels of an inhibitory interneuron have on the firing frequency of a finically active neuron that interneuron synapses onto? Explain in detailsExplain how the changes in Na+ and K+ ion concentrationsthat occur during an action potential are associated withdepolarization and repolarization.Which of the following is the most direct result of depolarizingthe presynaptic membrane of an axon terminal?(A) Voltage-gated calcium channels in the membrane open.(B) Synaptic vesicles fuse with the membrane.(C) Ligand-gated channels open, allowing neurotransmittersto enter the synaptic cleft.(D) An EPSP or IPSP is generated in the postsynaptic cell.
- Since neurotransmittersare not consumed in thesynaptic process, what are themechanisms to reduce theirconcentrations in the synapticcleft after they have beenused?explain the simplified version of the synaptic process resulting in long-term potentiationand explain the roles of AMPA and NMDA receptors; glutamate; sodium, calcium, and magnesium ions in strengthening a synapse.Describe how resting potential is form in a neuron. Key difference from in and out a neuron and how they are maintain and proteins involved.