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Muscle Contraction
In an experiment, the strength of a neural stimulus and the resulting muscle contraction are compared. A single motor neuron that synapses with one muscle fibre is observed in this experiment. One end of the muscle fibre is attached to a mass. The following data were obtained from the experiment.
| Number of Trials | Strength of Stimulus (mV) | Mass Lifted by Muscle Contraction (g) |
|---|---|---|
| 1 | 20 | 0 |
| 2 | 40 | 0 |
| 3 | 60 | 50 |
| 4 | 80 | 50 |
| 5 | 100 | Not Tested |
| 6 | 120 | 50 |
Identify the manipulated, responding and controlled variables in the experiment described above.
| Strength of Stimulus |
|
| Number of Muscle Fibre Stimulated |
|
| Mass Lifted by Muscle Contraction |
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- Muscle Contraction In an experiment, the strength of a neural stimulus and the resulting muscle contraction are compared. A single motor neuron that synapses with one muscle fiber is observed in this experiment. One end of the muscle fiber is attached to a mass. The following data was obtained from the experiment. *attached document is chart with data 1. Does the data in the table provide sufficient evidence of the value for the threshold potential? Why or why not 2.a) A student remarked that at 180 mV of stimulus, it is expected that 100 g mass is lifted by the muscle fiber.b)Do you agree or disagree? Why or why not? 3.Identify the manipulated, responding and controlled variables in the experiment described above a) strength of stimulus ________ (manipulated, responding, or controlled) b) number of mucsle fibre stimulated _____ (maniuplated, repsonding, or controlled) c) mass lifted by muscle contraction ______ (manipulated, responding or controlled) 4. How would you modify this…1. How would you modify this experiment so that the mass lifted by the muscle contraction continues to increase for every trial? 2. A pin can be pressed against the skin lightly and elicit no response from the pain receptor. However, if the pin is jabbed into the finger, the pain receptor may be stimulated and the finger would quickly be withdrawn through a reflex arc. Use what you know about threshold potential and the all-or-none principle to explain different levels of sensation (light touch or pain).The motor unit firing patterns are measured in a human hand muscle using an electromyography (EMG) recording. Which one of the following statements is the best description of the EMG pattern observed as the individual voluntarily attempts to make a low-level force of contraction in the muscle and steadily increases the force of contraction? Low amplitude spikes visible on the EMG trace at low force. Larger amplitude spikes become visible with increasing force of contraction. Low frequency of small amplitude spikes on the EMG trace at low force. Spike frequency and amplitude increase with increasing force. A large single deflection in the trace as the individual contracts the muscle. The deflection gets larger with increasing force. Low frequency of spikes on the EMG trace at low force. The frequency of spikes becomes more frequent with increasing force.
- An effector neuron is a motor neuron that transmits impulses from the CNS to an effector (muscle or gland).In an experiment, it was determined that the effector neuron for muscle fibre 1 had a threshold level of –5 mV. The effector neuron for muscle fibre 2 had a threshold level of –16 mV. An electrical probe was used to stimulate these two effector neurons of the muscle fibres. Which of the following rows correctly identifies the reaction of each muscle fibre based on the applied stimulus voltage? Stimulus Voltage Muscle Fibre 1 Muscle Fibre 2 –20 mV Relaxed Contracted b. Stimulus Voltage Muscle Fibre 1 Muscle Fibre 2 –20 mV Contracted Relaxed c. Stimulus Voltage Muscle Fibre 1 Muscle Fibre 2 –10 mV Contracted Relaxed d. Stimulus Voltage Muscle Fibre 1 Muscle Fibre 2 –10 mV Relaxed ContractedThe single-fiber twitch experiments shown here were generated by stimulating the muscle cell membranes to threshold with an electrode and measuring the resulting action potential and force. How would the results differ if Ca21 were removed from the extracellular solution just before the electrical stimulus was applied?4) You set up an experiment using an isolated mouse muscle-nerve preparation.a. Draw the force traces (used to measure the force of contraction using a force transducer) you wouldexpect to get if you stimulated the nerve at 3 different lengths: 1) slack, 2) the normal length of the musclein the body, and 3) stretched past a length the muscle could ever experience in a mouse. If the force tracesare different explain why. (Hint: refer back to the length-tension relationship)b. Draw the nerve signals you would record from a Group Ia muscle spindle afferent at each of those 3lengths. If the 3 conditions are different explain why. (Hint: refer back to the function of the musclespindle
- Why does muscle CAP Amp for both the normal Ringer's solution and Ringer's solution with Neostigmine increased as the stimulus amplitude increased, but a normal Ringer's solution would have a larger muscle CAP Amp value? Why is this the same case for a CAP Period as stimulus amplitude increases?. Why would Muscle CAP Period values for Ringer's with NEO then have larger values. Why does a normal Ringer's solution take longer to reach maximum action potential ?Article: Effect of Patterned Electrical Neuromuscular Stimulation on Vertical Jump in Collegiate Athletes This article presents research evidence regarding PENS (patterned electrical neuromuscular stimulation) and it’s effects on vertical jump of athletes. Please show a-e. a.) background b.) purpose c.) methods d.) results e.) conclusion Lastly, Reflect on the article. What did you learn? What made sense? What did you not understand or was confusing? What did you agree or disagree with? Do you have follow-up questions? How does this data apply to clinical practice? Will you clinically use this data?What is the role of calcium in muscle contractions? Multiple Choice a) To spread the action potential through the T-tubules b) To bind with troponin, changing its shape so that binding sites on the actin filament are exposed c) To transmit the action potential across the neuromuscular junction d) To re-establish the polarization of the plasma's membrane following an action potential e) To break the cross-bridges as a cofactor in the hydrolysis of ATP
- The figure below shows the muscle tension (Y axis) following the application of stimuli to the muscle fiber. The pink arrows on the bottom symbolize stimuli to the muscle cell. The best explanation that the tension of the contraction in panel 4 is larger than other panels is because: A. More motor units are recruited B. More muscles are contracting C. The duration of the stimuli is longer D. The frequency of the stimuli is greaterThe electrochemical gradient of a muscle cell at rest or its resting membrane potential is slightly negative inside the plasma membrane and slightly positive just outside the plasma membrane and has an ionic gradient of more potassium ions inside the cell and more sodium ions outside the cell. Therefore, a muscle cell at rest is said to be __________________ and has membrane potential. about to exocytose synaptic vesicles containing acetylcholine polarized experiencing an action potential about to allow an influx of potassium ions into the cell depolarizedA research scientist is developing a new drug that blocks muscle cellreceptors that, when activated, stimulate a muscle contraction. In her firstexperiment, she used 250 mg of the new drug but saw no effect. In hersecond experiment, she increased the dosage to 750 mg. This dosagewas successful in blocking the muscle stimulation. Explain why increasingthe dosage would affect the outcome of the experiment.