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If a mutation that inactivated telomerase occurred in a
cell (telomerase activity in the cell = zero), what do you
expect the outcome to be?
Step by step
Solved in 3 steps
- Why do adult human cells (other than germ cells and stem cells) NOT express the enzyme telomerase? In other words what benefit does not having telomerase provide to these cells?Budding yeasts such as S. cerevisiae exhibit telomerase activity throughout their life cycles, whereas human somatic cells do not exhibit telomerase activity. Suggest why this is so.Telomerase activity has been found to be 10 to 20 times more active in cancer cells than in normal somatic cells. What is the significance of this circumstance?
- In your own words, explain how cancer cells differ from normal cells in regard to the following: Telomeres, which are products of telomerase enzymeThe enzyme telomerase is part protein and part RNA. What would be the most likely effect of a large deletion in the gene that encodes the RNA component of telomerase? How would the function of telomerase be affected?Telomeres contain a 3′ overhang region, as shown. Does telomerase require a 3′ overhang to replicate the telomere region? Explain.
- Choose the combination of answers that most accurately completes the statement.Which of the following sequences, when combined with its complement, would be clipped by a restriction endonuclease? a. ATCGATCGTAGCTA c. GAATTC b. AAGCTTCGAA d. ACCATTGGAHow could telomerase inhibitors be used to treat cancer?In producing genetically engineered human insulin in bacteria, why is it important to use the samerestriction enzyme to cut both the human DNA and the bacterial plasmid?
- How is telomerases related to ageing? How Can telomerase- related ageing be addressed therapeutically?Why would telomerase be considered a reverse transcriptase?How is telomerase related to aging? How can telomerase-related aging beaddressed therapeutically? What is a potential danger of telomerase activation?