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If transplanting a solid organ such as a kidney, why is MHC II matching also important to success of the graft?
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- MHC class I molecules present peptide antigens derived from a(n) _______ compartment, whereas MHC class II molecules present peptide antigens derived from a(n) _______ compartment: a. extracellular; intracellular b. intracellular; extracellular c. opsonization; neutralization d. neutralization; opsonization e. none of the above.What is the function of MHC? Which cells make MHC I, and which make MHC II? What WBCs can present antigens in MHC II?What are side effects most common to immunosuppressive therapy? Why there is a high risk of lymphoproliferative diseases?
- What is the major cell type involved in graft rejection?In terms of antigens and antibodies, explain why O- is considered a universal donor and why AB+ is considered a universal recipient. Even so, why can’t whole blood O- be donated to a person of type AB+ blood?Can we discuss the similarities and differences between MHC I and MHC II due to their different presentations and expressions?
- Why does antibody titer rise after infection? Is ahigh antibody titer indicative of an ongoing infection?ExplainWhat is the appropriate response when antigen is presented on MHC class II molecules?a) An effector CD8 cell should kill the presenting cell.b) An effector CD4 cell should kill the presenting cell.c) An effector CD8 cell should activate the presenting cell.d) An effector CD4 cell should activate the presenting cell.There is a variety of organs routinely transplanted in clinical medicine. Knowing that organ transplantation is routinely performed in clinic answer the following: What is a significance of HLA-typing used to match with the most suitable recipient? What has been achieved by using powerful immunosuppressive drugs?
