I'm having some trouble with this practice problem from my study guide. If anyone can explain it it would be very helpful! Sometimes nondisjunction will occur in a parent that has normal chromosome numbers and result in an offspring that has abnormal

Human Physiology: From Cells to Systems (MindTap Course List)
9th Edition
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Lauralee Sherwood
Chapter20: The Reproductive System
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Hi, I'm having some trouble with this practice problem from my study guide. If anyone can explain it it would be very helpful!

  1. Sometimes nondisjunction will occur in a parent that has normal chromosome numbers and result in an offspring that has abnormal number of chromosomes. The phenotype of the affected offspring will often allow geneticists to determine in which parent and during which division of meiosis the nondisjunction occurred. In each of the examples below, assume the parents have a normal diploid chromosome complement.

EXAMPLE 1: A man with the X-linked dominant condition “brown tooth enamel” and a woman with normal tooth enamel produce a son with brown tooth enamel. Let’s call the allele for brown tooth enamel “XB” and normal tooth enamel “Xb”.

  1. In which parent did the nondisjunction occur? Explain and/or illustrate
  2. Did nondisjunction occur at meiosis I or II? Explain and/or illustrate.
  3. What sex chromosomes are in the child’s somatic cells?

EXAMPLE 2: The parents in the family above produce another son, this time with two Y chromosomes and normal tooth enamel.

  1. In which parent did the nondisjunction occur? Explain and/or illustrate.
  2. Did nondisjunction occur at meiosis I or II? Explain and/or illustrate.
  3. What sex chromosomes are in the child’s somatic cells?

 

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