In a diagnostic examination of a patient’s thyroid, the patient, who weights 70 kg, is given a capsule containing 10 micro Ci 131I. Thirty percent of the radioiodine is rapidly taken up by the thyroid, whose weight is estimated as 30 g. Given that 1) the biological half-life of iodine in the thyroid is 120 days, 2) the radiological half-life 131I is 8 days, and 3) the average absorbed energy in the thyroid is 0.21 MeV per disintegration, calculate the a) effective half-life of the radioiodine in the thyroid, in days, b) effective turnover rate of the radioiodine in the thyroid, in percent day-1, c) mean residence time of the radioiodine in the thyroid, in days, d) time for 90% of the radioiodine to be cleared from the thyroid, and e) committed dose to the thyroid, in cGy

Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
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Chapter24: Reproductive System Drug
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In a diagnostic examination of a patient’s thyroid, the patient, who weights 70 kg, is given a capsule containing 10 micro Ci 131I. Thirty percent of the radioiodine is rapidly taken up by the thyroid, whose weight is estimated as 30 g. Given that 1) the biological half-life of iodine in the thyroid is 120 days, 2) the radiological half-life 131I is 8 days, and 3) the average absorbed energy in the thyroid is 0.21 MeV per disintegration, calculate the a) effective half-life of the radioiodine in the thyroid, in days, b) effective turnover rate of the radioiodine in the thyroid, in percent day-1, c) mean residence time of the radioiodine in the thyroid, in days, d) time for 90% of the radioiodine to be cleared from the thyroid, and e) committed dose to the thyroid, in cGy

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