In looking at the 3 lines of defenses of the immune system what are the similarities and differences?

Clonal Selection Hypothesis is the most accepted theory for how immune cells respond to specific antigens.   Explain the clonal selection hypothesis. Use the autoimmune response, and immunological memory to suggest why the hypothesis may be correct….or not?

Johnny has just been infected and needs your help in letting him know how his body is fighting the infection. To do so, describe how the innate and adaptive immune systems work together. You should address the following: 1. define adaptive and innate immunity; 2. Describe the role of natural killer cells (how do they work); 3. what are antigen presenting cells and what is their function, what are MHCs?; 4. describe the role of the complement system; 5. what is the role of interferons?; 6. How do helper T cells, cytotoxic T cells and B lymphocytes work make sure you address adaptive immunity memory?; 7. Define HIV, which cells do they attack and why do some individuals develop persistent lymphadenopathy (swollen or enlarged lymph nodes)?

How can your body make so many different antibodies (proteins) from just a select set of genes?

eds Antibodies (Immunoglobulins) Objective 14 Antibodies (immunoglobulins) are glycoproteins secreted by plasma cells. They are located in interstitial fluid, plasma (gamma globulin fraction) and in body secretions. onse A. Antibody Structure Heavy chain Antigen-binding site Light chain Insmakamos Hinge region Complement- binding site Stem region Macrophage binding site OHO (a) Antibody molecule OHO X = Disulfide bond Carbohydrate four polypeptide chains (two heavy, two light) chains are held together by covalent disulfide bonds (S=S) each heavy chain and each light chain has two functional areas: consists of highly variable amino acid sequences which forms the basis of antibody specificity; antigen binds here ????? to more conserved amino acid sequences; there are five basic sequences of amino acids, which define the 5 antibody classes (IgG, IgA, IgM, IgE and IgD); ????? each class has its own characteristic set of effector functions (see next page) Your notes: 4 40 4. 39