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In the stomach, parietal cells are responsible for the formation of the gastric juice. During acid secretion, the pH in the stomach is estimated to be pH= 2, whereas parietal cells maintain an intracellular pH = 7.35. The transmembrane potential of parietal cells is typically -70 mV. Body temperature 37°C. 1) Calculate the proton gradient concentration across the parietal membrane 2) Calculate the free energy change associated with the secretion of 1 mole of H*

In the stomach, parietal cells are responsible for the formation of the gastric juice. During acid secretion, the pH in the stomach is estimated to be pH= 2, whereas parietal cells maintain an intracellular pH = 7.35. The transmembrane potential of parietal cells is typically -70 mV. Body temperature 37°C. 1) Calculate the proton gradient concentration across the parietal membrane 2) Calculate the free energy change associated with the secretion of 1 mole of H*

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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In the stomach, parietal cells are responsible for the formation of the gastric juice. During acid secretion, the pH in the stomach is estimated to be pH = 2, whereas parietal cells maintain an intracellular pH =7.35. The transmembrane potential of parietal cells is typically -70 mV. Body temperature 37°C. 1) Calculate the proton gradient concentration across the parietal membrane 2) Calculate the free energy change associated with the secretion of 1 mole of H* 3) Do you think that Ht transport can be driven by ATP hydrolysis at the ratio of one molecule of ATP per H* transported? You can use your textbook or other sources to check AG for ATP hydrolysis 4) If H* where free to move back to into the cell, calculate the membrane potential that would be required to prevent them to do so
Transcribed Image Text:In the stomach, parietal cells are responsible for the formation of the gastric juice. During acid secretion, the pH in the stomach is estimated to be pH = 2, whereas parietal cells maintain an intracellular pH =7.35. The transmembrane potential of parietal cells is typically -70 mV. Body temperature 37°C. 1) Calculate the proton gradient concentration across the parietal membrane 2) Calculate the free energy change associated with the secretion of 1 mole of H* 3) Do you think that Ht transport can be driven by ATP hydrolysis at the ratio of one molecule of ATP per H* transported? You can use your textbook or other sources to check AG for ATP hydrolysis 4) If H* where free to move back to into the cell, calculate the membrane potential that would be required to prevent them to do so
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