In this case a family history revealed a genetic basis for the disorder. The pedigree is shown in Fig. 1 Below. Key Ø Female: affected Female: unaffected I IV V o 6000 600 10d60 5ம் 00000 10 CHO 80 Male: affected Male: unaffected Deceased Disease status not given Dizygotic twins Monozygotic twins Fig. 1 Disease pedigree. Five generations I, II, III, IV, V are shown. Females are represented by circles, males by squares, dizygotic (non-identical) twins by diagonal lines originating from the same point, Monozygotic (identical) twins by diagonal lines originating from the same point and joined symbols and deceased by a diagonal line through the symbol. Filled symbols indicate that the individual displays the disease phenotype. Unfilled symbols indicate that the individual does not display the disease phenotype. Carriers of the disease are not indicated. Information on disease status is not known for generation I and is omitted for the individuals represented by a symbol with an asterisk. The person referred to in the opening paragraph above is V.1. Consider which pattern(s) of Mendelian inheritance is fare) sunnested by this periores and then answer questions 4-6

In this case a family history revealed a genetic basis for the disorder. The pedigree is shown in Fig. 1 Below. Key Ø Female: affected Female: unaffected I IV V o 6000 600 10d60 5ம் 00000 10 CHO 80 Male: affected Male: unaffected Deceased Disease status not given Dizygotic twins Monozygotic twins Fig. 1 Disease pedigree. Five generations I, II, III, IV, V are shown. Females are represented by circles, males by squares, dizygotic (non-identical) twins by diagonal lines originating from the same point, Monozygotic (identical) twins by diagonal lines originating from the same point and joined symbols and deceased by a diagonal line through the symbol. Filled symbols indicate that the individual displays the disease phenotype. Unfilled symbols indicate that the individual does not display the disease phenotype. Carriers of the disease are not indicated. Information on disease status is not known for generation I and is omitted for the individuals represented by a symbol with an asterisk. The person referred to in the opening paragraph above is V.1. Consider which pattern(s) of Mendelian inheritance is fare) sunnested by this periores and then answer questions 4-6

Name: In this case a family history revealed a genetic basis for the disord
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Description: In this case a family history revealed a genetic basis for the disorder. The pedigree is shown in Fig. 1 Below.KeyØFemale: affectedFemale: unaffectedI||IVVTOLO5DO머910a. Any of these options is possibleb. III.5 but not V.3 would display the diseaseO

BIOLOGY:CONCEPTS+APPL.(LOOSELEAF)

10th Edition

ISBN:9781305967359

Author:STARR

Publisher:STARR

Chapter14: Human Inheritance

Section: Chapter Questions

Problem 9SA: Alleles for Tay-Sachs disease are inherited in an autosomal recessive pattern. Why would two parents...

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Examine the following pedigrees. Which is the most likely mode of inheritance of each disorder? (a) autosomal recessive (b) autosomal dominant (c) X-linked recessive (d) a, b, or c (e) a or c 10.
Using the pedigree chart, explain: a) The number of generations seen. b) If all blue-coloured shapes are affected with disease X- how many males are affected? how many females are affected? c) Does this disease have a dominant or recessive inheritance pattern? Justify your answer.
Hemochromatosis is an inherited disease caused by a recessive allele. If a woman and her husband, who are both carriers, have three children,what is the probability of each of the following? (a) All three children are of normal phenotype. (b) One or more of the three children have the disease. (c) All three children have the disease. (d) At least one child is phenotypically normal.
Duchenne muscular dystrophy is sex linked and usuallyaffects only males. Victims of the disease become progressively weaker, starting early in life.a. What is the probability that a woman whose brotherhas Duchenne’s disease will have an affected child?b. If your mother’s brother (your uncle) had Duchenne’sdisease, what is the probability that you have receivedthe allele?c. If your father’s brother had the disease, what is theprobability that you have received the allele?
a) A woman who is type A has a daughter who is type O. Give the genotypes of both the mother and of the daughter. b) The mother claims a man who is type B is the father. Is that possible? Explain. c) The accused man can prove that both of his parents are type AB. Is it possible for him to be type B? If so, what is his genotype? d) Does the answer in part c change the answer in part b?
Marfan’s syndrome is a disorder of the fibrous connective tissue, characterized by many symptoms, includinglong, thin digits; eye defects; heart disease; and long limbs. (Flo Hyman, the American volleyball star, suf-fered from Marfan’s syndrome. She died from a ruptured aorta.) a. Use the pedigree above to propose a mode of in-heritance for Marfan’s syndrome. b. What genetic phenomenon is shown by this pedigree?c. Speculate on a reason for such a phenomenon.
a)recessive epistasis b)duplicate recessive epistasis c)normal non-allelic gene interaction d)normal allelic gene interaction
A young couple went to see a genetic counselor because each had a sibling with cystic fibrosis. (Cysticfibrosis is a recessive disease, and neither member ofthe couple nor any of their four parents is affected.)a. What is the probability that the female of thiscouple is a carrier?b. What are the chances that their child will havecystic fibrosis?c. What is the probability that their child will be acarrier of the cystic fibrosis disease allele?
In a trait that follows Mendelian rules of inheritance, what is the only way an organism can have the recessive phenotype? A. By having the homozygous recessive genotype B. By being heterozygous for that genotype C. It is not possible to get the recessive phenotype in Mendelian genetics D. If one parent is homozygous recessive for that trait, any offspring are guaranteed the recessive phenotype E. By being homozygous dominant for that genotype
If a man with blood type AB marries a woman with blood type B whose father was type O, what phenotypes could their children have? a. A onlyb. A, AB, B, and Oc. AB onlyd. A, AB, and Be. O only
Which of the following CANNOT be true about the inheriteance the trait depicted in the pedigree diagram below? A. It is recessive B. It is dominant C. It is on the X chromosome D. It is recessive, and it is on the X chromosome
A couple who are about to get married learn from studying their family histories that, in both their families, theirunaffected grandparents had siblings with cystic fibrosis(a rare autosomal recessive disease).a. If the couple marries and has a child, what is theprobability that the child will have cystic fibrosis?b. If they have four children, what is the chance that thechildren will have the precise Mendelian ratio of 3:1 fornormal:cystic fibrosis?c. If their first child has cystic fibrosis, what is theprobability that their next three children will be normal?