L-Dopa (Levodopa) is an oral medication used to treat Parkinson's disease, the symptoms of which result from a lack of dopamine in the brain. L-Dopa relies on L-type, or leucine-preferring, transport proteins to cross the blood-brain barrier, and it is converted to dopamine in the brain by the enzyme aromatic-L-amino-acid decarboxylase. Properties of L-Dopa: • density: 1.47 g/cm melting point: 278 °C • boiling point: decomposes solubility in water: low solubility • solubility in lipids: low solubility • rotates plane-polarized light counterclockwise Classify each property based on whether it is or is not a property of

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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L-Dopa (Levodopa) is an oral medication used to treat
Parkinson's disease, the symptoms of which result from a
lack of dopamine in the brain. L-Dopa relies on L-type, or
leucine-preferring, transport proteins to cross the blood-brain barrier,
and it is converted to dopamine in the brain by the enzyme
aromatic-L-amino-acid decarboxylase.
Properties of L-Dopa:
density: 1.47 g/cm
• melting point: 278 °C
• boiling point: decomposes
solubility in water: low solubility
• solubility in lipids: low solubility
• rotates plane-polarized light counterclockwise
Classify each property based on whether it is or is not a property of
L-Dopa's enantiomer, D-Dopa.
Transcribed Image Text:L-Dopa (Levodopa) is an oral medication used to treat Parkinson's disease, the symptoms of which result from a lack of dopamine in the brain. L-Dopa relies on L-type, or leucine-preferring, transport proteins to cross the blood-brain barrier, and it is converted to dopamine in the brain by the enzyme aromatic-L-amino-acid decarboxylase. Properties of L-Dopa: density: 1.47 g/cm • melting point: 278 °C • boiling point: decomposes solubility in water: low solubility • solubility in lipids: low solubility • rotates plane-polarized light counterclockwise Classify each property based on whether it is or is not a property of L-Dopa's enantiomer, D-Dopa.
Property of D-Dopa
Not a Property of D-Dopa
rotates plane-polarized light clockwise
reduces symptoms of Parkinson's disease
highly soluble in water
aromatic-L-amino-acid decarboxylase has
a different affinity for D-Dopa
density slightly less than that of L-Dopa
good substrate for aromatic-L-amino-acid
decarboxylase
solid at room temperature
Transcribed Image Text:Property of D-Dopa Not a Property of D-Dopa rotates plane-polarized light clockwise reduces symptoms of Parkinson's disease highly soluble in water aromatic-L-amino-acid decarboxylase has a different affinity for D-Dopa density slightly less than that of L-Dopa good substrate for aromatic-L-amino-acid decarboxylase solid at room temperature
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