Match these cell cycle checkpoints to their role in genome integrity Is the DNA replicated with out damage? [ Choose] [Choose ] M Are the chromosomes lined up correctly attached to the mitotic spindle? Intra-S (during S-phase) G1/S G2 Does the cell have a enough nutrients, proteins and growth factors? [ Choose] [ Is the cellular DNA badly damaged during the replication process? [Choose ] > >

Match these cell cycle checkpoints to their role in genome integrity Is the DNA replicated with out damage? [ Choose] [Choose ] M Are the chromosomes lined up correctly attached to the mitotic spindle? Intra-S (during S-phase) G1/S G2 Does the cell have a enough nutrients, proteins and growth factors? [ Choose] [ Is the cellular DNA badly damaged during the replication process? [Choose ] > >

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter28: Dna Metabolism: Replication, Recombination, And Repair

Section: Chapter Questions

Problem 19P: Figure 28.11 depicts the eukaryotic cell cycle. Many cell types â€œexitâ€� the cell cycle and...

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Figure 28.11 depicts the eukaryotic cell cycle. Many cell types â€œexitâ€� the cell cycle and donâ€™t divide for prolonged periods, a state termedG0; some, for example neurons, never divide again. a. In what stage of the cell cycle do you suppose a cell might be when it exits the cell cycle and enters G0? b. The cell cycle is controlled by checkpoints, cyclins, and CDKs. Describe how biochemical events involving cyclins and CDKs might control passage of a dividing cell through the cell cycle.
Match the process with the correct phase of the cell cycle (G1, S, G2, M). If the process occurs in M phase indicate subphase (ex. telophase). E) ___________________Extra cell membrane is synthesized by the smooth ER. F) ___________________DNA is compacted into chromatin.
Match the process with the correct phase of the cell cycle (G1, S, G2, M). If the process occurs in M phase indicate subphase (ex. telophase). A) ___________________ The bipolar spindle forms from microtubules. B) ___________________ The nucleus breaks down. C) ___________________ Mitochondria are duplicated. D) ___________________Sister chromatids are formed. E) ___________________Extra cell membrane is synthesized by the smooth ER. F) ___________________DNA is compacted into chromatin.
At the end of which phase(s) of the mitotic cell cycle does each chromosome consist of two sister chromatids? Indicate all correct answers – more than one answer is correct. a) G1 of interphase b) G2 of interphase c) anaphase d) metaphase e) prophase f) telophase
What celluar events/processes are associated with G1,S,G2,and M phases of the cell cycle? With the phases of mitosis? Some example: A. DNA replication B. Beginning of mitosis C. Normal cell growth and function D. Breaksdown of nuclear membrane E.Separation of sister chromatids F.Alignment of chromosomes on the equator of the cell H.Triggering the compaction and condensation of chromosomes I. Attachment of microtubles to kinetochores
What are cell cycle checkpoints? Where in the cell cycle are the checkpoints found (note—incude S phase checkpoint? How do they differ? How are Rb, p53, and MPF involved in cell cycle checkpoints? What events could lead to cell cycle arrest?
BPA is a chemical compound that has historically been used in themanufacture of plastic products. However, cells often mistake BPAcompounds for hormones that accelerate the cell cycle. Because ofthis, BPA is associated with an increased risk of certain cancers. Question: How might BPA interact with the cell cycle and its checkpoints?
Indicate the stage of mitosis (interphase = I, prophase = P, metaphase = M, anaphase = A, telophase = T) during which each of the following events occur. chromatid doublets separate to individual chromosomescentriole replicatesreplicated chromosomes (chromatid doublets) are arranged in single file next to one another at the cell's equatornuclear membrane is disappearingspindle fibers form and become visiblecell plate (plant) or cleavage furrow (animal) forms and is visiblechromosomes are at opposite poles of the cell; cytokinesis is almost completedchromosomes (chromatids) first become visible as long thin strandsDNA (chromosome) replication occurs
How can defects in the regulation of cell-cyle checkpoints would affect cells and explain how these defects relate to uncontrolled division in cancer and cancer progression? Describe the movements of chromosomes and the status of the microtubules spindle during interphase, prophase, metaphase, anaphase, and telophase? Explain the movement of chromosomes during stages of meoisis to produce sperm and eggs?
Are replicated chromosomes are positioned on the cell’s equator anaphase, metaphase, or telophase? Are nuclear envelopes form around chromosomes and spindle fibers break down anaphase, metaphase, or telophase?
Passage of cells from G1 through R to S depends on the interaction of various signal molecules, proteins and enzymes which regulate the cell cycle. Imagine I have just induced a mutation in a cell line which prevents the breakdown of the cyclin molecule we discussed. Which of the following events do you predict will happen? circle all that apply Select one or more: a. Uncontrolled cell replication may result b. Retinoblastoma protein will be continuously active c. The cells will be stuck in G1 phase d. The cells will begin to replicate their DNA e. Cyclin dependent kinase (Cdk) will be continuously active
Progression through the cell cycle is dependent on both extra- and intracellular conditions. Consider the following conditions. Indicate which checkpoint (s) responds to that condition.a. The cell is large enough to divide.b. The DNA is completely copied during S phase.c. The cell is receiving positive cues from neighbors.d. The DNA is damaged.e. The cell has enough energy reserves to divide.f. Are all the sister chromatids correctly attached to spindle microtubules?