Mechanism of C1,C2-diether and C2-monoether derivatives of lycorine with explanation

Anatomy & Physiology
1st Edition
ISBN:9781938168130
Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Chapter18: The Cardiovascular System: Blood
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Problem 29CTQ: True or false: The buffy coat is the portion of a blood sample that is made up of its proteins.
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Mechanism of C1,C2-diether and C2-monoether derivatives of lycorine with explanation

он
HO..
OR
RO.,
OR
HO.,
12
RX (2.5 eq), NaH
D.
N'
DMF, rt, 2-20 h
3 (41%) R = Me
4а-10а, 13а, 15а-17а,
19а, 20а
14-90%
2b, 6ь, 7Ь, 10b, 13Ь-20b
5-36%
OSi(-Pr)a
OSi(-Pr)a
он
OR
HO.
(-Pr),Sio,
(-Pr),SiO.,
-Pr3SICI
Py. DMF
RO.,
RX, NaH,
DMF, rt, 20h
79%
28
22 (18%)
23 (13%), 24 (16%)
11, 21, 25-27
8-21%
TBAF 53%
THE
он
RO.
12 R= Me
Transcribed Image Text:он HO.. OR RO., OR HO., 12 RX (2.5 eq), NaH D. N' DMF, rt, 2-20 h 3 (41%) R = Me 4а-10а, 13а, 15а-17а, 19а, 20а 14-90% 2b, 6ь, 7Ь, 10b, 13Ь-20b 5-36% OSi(-Pr)a OSi(-Pr)a он OR HO. (-Pr),Sio, (-Pr),SiO., -Pr3SICI Py. DMF RO., RX, NaH, DMF, rt, 20h 79% 28 22 (18%) 23 (13%), 24 (16%) 11, 21, 25-27 8-21% TBAF 53% THE он RO. 12 R= Me
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