6) Draw the chemical structure for the maior metabolite for the following reactions and include the name of the cofactor (if required). a. -CH3 CH3 N-Dealkylation CH3 NO reaction CYP CI Buproprion b. *most common phase II route HO UGT UDPGA GA-0 + UDP N-Dealkylation: Selectivity • N-dealkylation is preferred for short (< 4 carbon) alkyl chain HN–CH3 HN CH3 4 No reaction H3C. NH 3 • A tertiary carbon group is more favored than a secondary carbon * Aromatic para hydroxylation N-dealkylation OH propranolol Have alot of metabolite
6) Draw the chemical structure for the maior metabolite for the following reactions and include the name of the cofactor (if required). a. -CH3 CH3 N-Dealkylation CH3 NO reaction CYP CI Buproprion b. *most common phase II route HO UGT UDPGA GA-0 + UDP N-Dealkylation: Selectivity • N-dealkylation is preferred for short (< 4 carbon) alkyl chain HN–CH3 HN CH3 4 No reaction H3C. NH 3 • A tertiary carbon group is more favored than a secondary carbon * Aromatic para hydroxylation N-dealkylation OH propranolol Have alot of metabolite
Chapter9: Alkynes: An Introduction To Organic Synthesis
Section9.SE: Something Extra
Problem 28AP
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Help me answer 6a based on my note it says no reaction for 4 carbons? how do i count carbons on chain? thank you
![6) Draw the chemical structure for the maior metabolite for the following reactions and include the
name of the cofactor (if required).
a.
-CH3
CH3
N-Dealkylation
CH3
NO reaction
CYP
CI
Buproprion
b.
*most common phase II route
HO
UGT
UDPGA
GA-0
+ UDP](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fc38faeb2-17ff-460b-9bc1-731b6d9cefb8%2F4edbe4de-046a-4772-8e4c-afe8dc17e83c%2Fpape9o_processed.jpeg&w=3840&q=75)
Transcribed Image Text:6) Draw the chemical structure for the maior metabolite for the following reactions and include the
name of the cofactor (if required).
a.
-CH3
CH3
N-Dealkylation
CH3
NO reaction
CYP
CI
Buproprion
b.
*most common phase II route
HO
UGT
UDPGA
GA-0
+ UDP
![N-Dealkylation: Selectivity
• N-dealkylation is preferred for short (< 4 carbon)
alkyl chain
HN–CH3
HN CH3
4
No reaction
H3C.
NH
3
• A tertiary carbon group is more favored than a
secondary carbon
*
Aromatic
para
hydroxylation
N-dealkylation
OH
propranolol
Have alot of metabolite](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fc38faeb2-17ff-460b-9bc1-731b6d9cefb8%2F4edbe4de-046a-4772-8e4c-afe8dc17e83c%2Fpd7x39_processed.png&w=3840&q=75)
Transcribed Image Text:N-Dealkylation: Selectivity
• N-dealkylation is preferred for short (< 4 carbon)
alkyl chain
HN–CH3
HN CH3
4
No reaction
H3C.
NH
3
• A tertiary carbon group is more favored than a
secondary carbon
*
Aromatic
para
hydroxylation
N-dealkylation
OH
propranolol
Have alot of metabolite
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