10. A 55-year-old woman presented to the hospital with complaints of muscleweakness, fatigue, night cramps, pain in the lumbar region. When fluoroscopyrevealed a decrease in bone density, a violation of bone structure. The patientwas diagnosed with osteoporosis («porous bones»). Osteoporosis is a commoncause of fractures of the spine, femur and forearm bones. The doctor prescribedtreatment with calcitriol and calcium supplements. Calcitriol receptors exist intwo allelic variants B and b. Studies have shown that dominant homozygotesBB are more susceptible to osteoporosis and this patient has this genotype.What are the other causes of osteoporosis and what is the mechanism of thetherapeutic effect of calcitriol? For answer:a) indicate the target organs of calcitriol;b) write a scheme for the calcitriol synthesis;c) describe the mechanism of calcitriol action on target cells;

Vitamin D deficiency : due to decreased l alpha-hydroxylase enzyme (renal failure, vitamin…

Answered: nicate the target organs of calcitriol;…

nicate the target organs of calcitriol; vrite a scheme for the calcitriol synthesis; lescribe the mechanism of calcitriol action on target cells:

Anatomy & Physiology

1st Edition

ISBN:9781938168130

Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble

Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble

Chapter6: Bone Tissue And The Skeletal System

Section: Chapter Questions

Problem 28RQ: How can a fractured diapliysis release fat globules into the bloodstream? The bone pierces fat...

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Question

10. A 55-year-old woman presented to the hospital with complaints of muscle
weakness, fatigue, night cramps, pain in the lumbar region. When fluoroscopy
revealed a decrease in bone density, a violation of bone structure. The patient
was diagnosed with osteoporosis («porous bones»). Osteoporosis is a common
cause of fractures of the spine, femur and forearm bones. The doctor prescribed
treatment with calcitriol and calcium supplements. Calcitriol receptors exist in
two allelic variants B and b. Studies have shown that dominant homozygotes
BB are more susceptible to osteoporosis and this patient has this genotype.
What are the other causes of osteoporosis and what is the mechanism of the
therapeutic effect of calcitriol? For answer:
a) indicate the target organs of calcitriol;
b) write a scheme for the calcitriol synthesis;
c) describe the mechanism of calcitriol action on target cells;

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Calcitriol : Active form of vitamin D

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Calcitriol synthesis

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