nucleation site and moved into the axon. It was noted in the text that cytoplasmic dynein is responsible for the retrograde movement of organelles in axons, yet this same motor is thought to mediate the anterograde movement of microtubules in these same cellular processes. How is it possible that the same minus end–directed motor can be involved in both anterograde and retrograde movements?

Biology 2e
2nd Edition
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark
Chapter9: Cell Communication
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Problem 1VCQ: Figure 9.8 HER2 is a receptor tyrosine kinase. In 30 percent of human breast cancers, HER2 is...
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The microtubules of an axon are thought to be nucleated at the centrosome, then severed from their nucleation site and moved into the axon. It was noted in the text that cytoplasmic dynein is responsible for the retrograde movement of organelles in axons, yet this same motor is thought to mediate the anterograde movement of microtubules in these same cellular processes. How is it possible that the same minus end–directed motor can be involved in both anterograde and retrograde movements?
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