OCH3 OS02CH3 ОСНЗ OCH3 Nat-o OCH3 "оСн, OCH3 one step vernakalant

Chemistry: The Molecular Science
5th Edition
ISBN:9781285199047
Author:John W. Moore, Conrad L. Stanitski
Publisher:John W. Moore, Conrad L. Stanitski
Chapter7: Molecular Structures
Section: Chapter Questions
Problem 66QRT
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Draw a stepwise mechanism for the following reaction, a key step in the synthesis of vernakalant, a drug approved in Europe in 2010 for the treatment of atrial fibrillation. Pure B was separated from a mixture of diastereomers. Your mechanism must explain the trans stereochemistry of the two substituents on the six-membered ring.

OCH3
OS02CH3
ОСНЗ
OCH3
Nat-o
OCH3
"оСн,
OCH3
one
step
vernakalant
Transcribed Image Text:OCH3 OS02CH3 ОСНЗ OCH3 Nat-o OCH3 "оСн, OCH3 one step vernakalant
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