One simplified way to understand these effects is to consider excitation and inhibitionsimply in terms of algebraic signs. We are all familiar with the effect of multiplyingpositive and negative numbers, which is the point of the exercise below.1. In Example below 1, how many ways can you produce a + result? A negative result?2. In example 2, how many ways can you produce a + result?3. In Example 3, what is the result without the box; with the box?1.x + = +32. The Different Effects of Excitation and Inhibition in Neural Circuit (series #1)|Neural circuit consists of polysynaptic neural network, combination of excitatory and inhibitoryneurons. This exercise helps to understand the effects of excitation and inhibition in the nervoussystem.Our body is dynamically active under physiology condition. As a result, there are basal levels ofactivity such as 70 beats/min of heart rate at resting condition. Either increased or decreasedactivities are relative to the baseline.The effects of excitation are easily understood---one neuron activates another neuron. However,when inhibition is introduced into circuits, analysis become more complicated. In fact, thenumbers of inhibitory neurons in the circuit determine the final effect of the circuit, which can beexcitation or inhibition, on the target organ or area.We assume all excitatory and inhibitory neurons are glutamate and GABA neurons, respectively,in this practice sheet. The glutamate and GABA neurons generate EPSP and IPSP, resulting indepolarization and hyperpolarization on the postsynaptic membrane, respectively.Excitatory neuronInhibitory neuron1.2.3.4.

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