Part III-PGD? Suzanne and David decided to have children. They wanted to ensure that their children would not inherit Suzanne's disease, and are now considering whether to utilize a process known as pre-implantation genetic diagnosis (PGD). This process involves in vitro fertilization (IVF) and genetic testing of the resulting embryos for the APP mutation. Only embryos without the mutated APP gene would be implanted. The others would be discarded. Should Suzanne and David have PGD? Questions 1. What is in vitro fertilization? Does it carry risk? How is the procedure accomplished?

Biology (MindTap Course List)
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Chapter1: A View Of Life
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Problem 17TYU: SCIENCE, TECHNOLOGY, AND SOCIETY In the future, gene technology may make it possible for parents to...
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Please help me answer Part III- 1, 2, 3, 4 of this case study,

Thank you,

Heres a link to the PDF

https://www.cusd80.com/cms/lib/AZ01001175/Centricity/Domain/8922/eofad.pdf

Part III-PGD?
Suzanne and David decided to have children. They wanted to ensure that their children would not inherit
Suzanne's disease, and are now considering whether to utilize a process known as pre-implantation genetic
diagnosis (PGD). This process involves in vitro fertilization (IVF) and genetic testing of the resulting embryos
for the APP mutation. Only embryos without the mutated APP gene would be implanted. The others would
be discarded.
Should Suzanne and David have PGD?
Questions
1. What is in vitro fertilization? Does it carry risk? How is the procedure accomplished?
2. Who has access to IVF/PGD? What would obstacles to access be? Are these procedures typically covered
by insurance?
3. Do women egg donors undergoing IVF incur any risk? If yes, what might those risks be? What about the
risks for the sperm donor? Why do people decide to continue with IVF knowing about potential risks?
4. What are the arguments/ethical issues surrounding this couple's use of IVF/PGD to determine the
inheritance of this particular disease gene? If screening for disease genes is okay, is it also okay to
screen for the sex of the child? If not, how would you describe the differences between the two types of
screening? What about other traits, such as physical attributes and intelligence? Please explain.
Resources
Grady, D. 2007. "Girl or Boy? As Fertility Technology Advances, So Does an Ethical Debate." New York
Times. Feb 6, 2007.
Grady, D. 2002. "Ideas and Trends: Genes, Embryos and Ethics." New York Times. March 3, 2002.
Harmon, A. 2006. "Couples Cull Embryos to Halt Heritage of Cancer." New York Times. Health. Sept. 3, 2006.
Josefson, D. 2002. Doctors successfully screen embryos for gene mutation linked to early onset Alzheimer's.
British Medical Journal 324(7337):564. Available online from PubMed at
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1172077. Last accessed: 2/28/08.
Kolata, G. 2002. "Fertility Society Opposes Choosing Embryos Just for Sex Selection." New York Times. Feb. 16, 2002.
Roberts, J.C. 2002. Customizing conception: A survey of preimplantation genetic diagnosis and the
resulting social, ethical, and legal dilemmas. Duke Law and Technology Review 0012.
http://www.law.duke.edu/journals/dltr/articles/2002dltro012.html. Last accessed: 2/28/08.
Simoncelli, T.M. 2003. Pre-Implantation Genetic Diagnosis: Ethical Guidelines for Responsible Regulation.
For: President's Council on Bioethics by The International Center for Technology Assessment.
http://www.icta.org/doc/pgd%20guidelines.pdf. Last accessed: 2/28/08.
Simoncelli, T.M. 2003. Pre-Implantation genetic diagnosis and selection: From disease prevention to
customized conception. Different Takes. No. 24 (Spring).
Spriggs, M. 2002. Genetically selected baby free of inherited predisposition to early-onset Alzheimer's disease.
Journal of Medical Ethics 28(5):290.
Towner, D., and R. Loewy. 2002. Ethics of preimplantation diagnosis for a woman destined to develop early-
onset Alzheimer disease. [Commentary.] Journal of the American Medical Association 287(8):1038-1040.
Verlinsky, Y., et al. 2002. Preimplantation diagnosis for early-onset Alzheimer disease caused by V717L
mutation. Journal of the American Medical Association 287(8):1018-1021.
"Living With Her Genes" by Gildensoph, Stanford, & Wygal
Page 5
Transcribed Image Text:Part III-PGD? Suzanne and David decided to have children. They wanted to ensure that their children would not inherit Suzanne's disease, and are now considering whether to utilize a process known as pre-implantation genetic diagnosis (PGD). This process involves in vitro fertilization (IVF) and genetic testing of the resulting embryos for the APP mutation. Only embryos without the mutated APP gene would be implanted. The others would be discarded. Should Suzanne and David have PGD? Questions 1. What is in vitro fertilization? Does it carry risk? How is the procedure accomplished? 2. Who has access to IVF/PGD? What would obstacles to access be? Are these procedures typically covered by insurance? 3. Do women egg donors undergoing IVF incur any risk? If yes, what might those risks be? What about the risks for the sperm donor? Why do people decide to continue with IVF knowing about potential risks? 4. What are the arguments/ethical issues surrounding this couple's use of IVF/PGD to determine the inheritance of this particular disease gene? If screening for disease genes is okay, is it also okay to screen for the sex of the child? If not, how would you describe the differences between the two types of screening? What about other traits, such as physical attributes and intelligence? Please explain. Resources Grady, D. 2007. "Girl or Boy? As Fertility Technology Advances, So Does an Ethical Debate." New York Times. Feb 6, 2007. Grady, D. 2002. "Ideas and Trends: Genes, Embryos and Ethics." New York Times. March 3, 2002. Harmon, A. 2006. "Couples Cull Embryos to Halt Heritage of Cancer." New York Times. Health. Sept. 3, 2006. Josefson, D. 2002. Doctors successfully screen embryos for gene mutation linked to early onset Alzheimer's. British Medical Journal 324(7337):564. Available online from PubMed at http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1172077. Last accessed: 2/28/08. Kolata, G. 2002. "Fertility Society Opposes Choosing Embryos Just for Sex Selection." New York Times. Feb. 16, 2002. Roberts, J.C. 2002. Customizing conception: A survey of preimplantation genetic diagnosis and the resulting social, ethical, and legal dilemmas. Duke Law and Technology Review 0012. http://www.law.duke.edu/journals/dltr/articles/2002dltro012.html. Last accessed: 2/28/08. Simoncelli, T.M. 2003. Pre-Implantation Genetic Diagnosis: Ethical Guidelines for Responsible Regulation. For: President's Council on Bioethics by The International Center for Technology Assessment. http://www.icta.org/doc/pgd%20guidelines.pdf. Last accessed: 2/28/08. Simoncelli, T.M. 2003. Pre-Implantation genetic diagnosis and selection: From disease prevention to customized conception. Different Takes. No. 24 (Spring). Spriggs, M. 2002. Genetically selected baby free of inherited predisposition to early-onset Alzheimer's disease. Journal of Medical Ethics 28(5):290. Towner, D., and R. Loewy. 2002. Ethics of preimplantation diagnosis for a woman destined to develop early- onset Alzheimer disease. [Commentary.] Journal of the American Medical Association 287(8):1038-1040. Verlinsky, Y., et al. 2002. Preimplantation diagnosis for early-onset Alzheimer disease caused by V717L mutation. Journal of the American Medical Association 287(8):1018-1021. "Living With Her Genes" by Gildensoph, Stanford, & Wygal Page 5
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