pela lei qu Nirmatrelvirola uvos orit tot meinerloom & wand A Give the reagents for A, B, and C to synthesize compound 4. To reiterate: the BOC group is large (not relevant here) and serves only to keep the nitrogen from getting involved in anything. T100193261 H―=H 1 =H 2 B 3 I N BOC 4

Organic Chemistry
9th Edition
ISBN:9781305080485
Author:John E. McMurry
Publisher:John E. McMurry
Chapter3: Organic Compounds: Alkanes And Their Stereochemistry
Section3.SE: Something Extra
Problem 53AP
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Question 2
I, we looked at the structure of Nirmatrelvir, half of the Pfizer COVID antiviral pill
Paxlovid. At first glance, the cyclopropylproline group (inside the dotted lines) seems
particularly challenging. However, that portion can be made from compound 4 below.
b) milapo
H =H
1
ods 1
F3C
NH
A
quo 008
Nirmatrelvir oydoo orli tol meinerloom's wa A
Give the reagents for A, B, and C to synthesize compound 4. To reiterate: the BOC group is
large (not relevant here) and serves only to keep the nitrogen from getting involved in anything.
2001///
==H
2
N
B
N
You
I
C
bit
BOC
4
Transcribed Image Text:Question 2 I, we looked at the structure of Nirmatrelvir, half of the Pfizer COVID antiviral pill Paxlovid. At first glance, the cyclopropylproline group (inside the dotted lines) seems particularly challenging. However, that portion can be made from compound 4 below. b) milapo H =H 1 ods 1 F3C NH A quo 008 Nirmatrelvir oydoo orli tol meinerloom's wa A Give the reagents for A, B, and C to synthesize compound 4. To reiterate: the BOC group is large (not relevant here) and serves only to keep the nitrogen from getting involved in anything. 2001/// ==H 2 N B N You I C bit BOC 4
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