Pluripotent stem cells undergo a number of changes as they progress through developmental stages to become the terminally differentiated cell type known as a skeletal muscle myofiber.  a) Describe the stages and key anatomic and functional changes that occur during differentiation of myofibers. b) Despite the fact that myofibers are terminally differentiated, muscle can regenerate itself following a trauma or injury.  Describe how this can occur.

Human Physiology: From Cells to Systems (MindTap Course List)
9th Edition
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Lauralee Sherwood
Chapter8: Muscle Physiology
Section: Chapter Questions
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Pluripotent stem cells undergo a number of changes as they progress through developmental stages to become the terminally differentiated cell type known as a skeletal muscle myofiber.  a) Describe the stages and key anatomic and functional changes that occur during differentiation of myofibers. b) Despite the fact that myofibers are terminally differentiated, muscle can regenerate itself following a trauma or injury.  Describe how this can occur. 

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