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- Problem 1) Tay-Sachs disease is caused by loss of function mutation in a gene on chromosome 15 that codes for an enzyme. The disease is an inherited autosomal recessive condition which is found amongst Ashkenazi Jews of Central European origin. In this population, 2 in 4,900 children are born with the disease. What proportion of the population are carriers (heterozygotes) for this disease? Problem 2) Skin colour in dolphins is determined by a single gene showing incomplete dominance giving rise to 3 phenotypes Brown, Pink & White. A survey of a large population of dolphins was carried out and the phenotypes recorded. However a student who had some of the data stored on their phone fell overboard and unfortunately the data was lost. The only data saved was that the brown homozygous dominants (BB) were 64% of the population . a) What would be the percentage of pink heterozygotes and white homozygotes? b) What percentage of the gametes that give rise to the next…Problem 4) About 7% of men in a population are red-green colour blind due to a sex-linked recessive gene. Assuming random mating in the population with respect to colour blindness; a) What percentage of women would be expected to be colour blind? b) What percentage of women would be expected to be heterozygous? c) What percentage of men would be colour blind in the next generation?Problem 2) Skin colour in dolphins is determined by a single gene showing incomplete dominance giving rise to 3 phenotypes Brown, Pink & White. A survey of a large population of dolphins was carried out and the phenotypes recorded. However a student who had some of the data stored on their phone fell overboard and unfortunately the data was lost. The only data saved was that the brown homozygous dominants (BB) were 64% of the population . a) What would be the percentage of pink heterozygotes and white homozygotes?
- Challenge Question! If a pregnant woman had a karyotype prepared for her baby before birth, would it be more useful in predicting the risk of Down Syndrome or Tay Sachs disease? Explain your answer completely and in detail.Problem 4: You are planning an experiment to use zinc finger nucleases to generate a double-stranded DNA break in a targeted sequence of DNA Name the protein domain in a zinc finger nuclease that is responsible for generating the DNA break Fok1 Name two other genome-engineering proteins that could be used for generating the double-stranded DNA break What are the advantages and disadvantages of each strategy?1.________ errors may be avoided by ensuring that the tools that are used in the experiment are properly calibrated. 2. _______ errors can be minimized by conducting many trials
- problem set 1 #25. What is Cot analysis? Do the Cot renaturation curves for a virus, bacterium, and yeast all roughly correspond to the size of their genomes?All questions a) What is the hypothesis of Griffith’s experiment? b) Why did mouse No. 3 survived? c) Why did mouse No. 4 died? d) If Griffith had injected a fifth mouse with a combination of heat-killed R strain bacteria and heat-killed S strain bacteria, would the mouse have died? Give your reason.Question:- 1. Brassica oleracea is the wild plant from which brussels sprouts, cabbage, broccoli, and cauliflower were domesticated. Why is it important to keep many diverse seeds from the forb B. oleracea across its range? A. If our B. oleracea-derived crops are driven to extinction, we can re-domesticate them from the wild plant. B. Our crop Brassicas are much more genetically diverse than B. oleracea because of extensive breeding programs, so we need to conserve as much of B. oleracea's diversity as possible. C. The budding pattern in Brassica may be further modified to produce more productive crop plants. D. B. oleracea may have gene variants that can be incorporated into our domesticated plants to increase their environmental range or tolerance to pests. E. We may be able to domesticate another crop plant from B. oleracea.
- Genetic application problems A woman with blood group 0 has had a child with blood group A. What is the child's genotype? And the phenotype of the father? Explain...Why ELSI Program is important for issues arising from the HGP ?Genetic application problems How can they be the children of a man from group A, whose mother was from group O, and a woman from group B, whose father was from group O? Make a well done crossbreeding scheme. Explain...