What the grandparents' genotypes are? Why doesn’t the father (II-1) have the disease breast cancer? What is the formal name for an individual having the gene but not showing the trait?
What the grandparents' genotypes are? Why doesn’t the father (II-1) have the disease breast cancer? What is the formal name for an individual having the gene but not showing the trait?
Chapter11: Cancer Prevention
Section: Chapter Questions
Problem 9AYK
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Question
What the grandparents' genotypes are?
Why doesn’t the father (II-1) have the disease breast cancer? What is the formal name for an individual having the gene but not showing the trait?
For this particular family, what is the recombination rate between the D17S74 marker and the breast cancer gene?
Transcribed Image Text:2
Flg. 1. Breast cancer families 1 to
7. Solid circles, females with
breast cancer; open circles, fe-
males without breast cancer; open
squares, males without breast
cancer. The age given for each
woman is age at (first) breast can-
cer diagnosis (dx) if affected, age
at death if deceased (deceased in-
dividuals are represented by diag-
onal lines through symbols), or
age at most recent interview if
alive without breast cancer. Al-
leles of D17S74 are shown for all
families and are lettered sequen-
dx 44
dx 45 dx 39
BA 80
65
BD AE
dx 41 dx 23
39
BA BE
DE
Expert Solution
Step 1 genetic inheritance
Genetic inheritance is the process by which genetic information is passed from the parents to the progeny
Types of genetic inheritance -;
- Autosomal dominant
- Autosomal recessive
- Sex linked recessive
- Sex linked dominant
- Mitochondrial inheritance
Factors affecting genetic inheritance --
- Mutation
- Environmental factors like radiation
- Age
- Genetic makeup
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