Problem : A liquid oral of drug 'x' was stored at 43.3, 51.5 and 71.67 °C. It was analyzed frequent intervals to determine the % of drug remaining and the results are given in th below table. The product becomes ineffective when 20% of the drug gets degrade Determine the shelf life of the product by accelerated stability testing method. S.NO Temperature, "C % of drug remaining after time in months 2 3. 4. 6. 10 1 43.30 100 79.43 63.1 31.62 ---- 51.50 100 66.06 44.66 29.51 13.18 ..-. .... 71.67 100 54.95 30.19 16.59 9.25 1Ew. 3

Fundamentals Of Analytical Chemistry
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Chapter28: Atomic Spectroscopy
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Problem : A liquid oral of drug 'x' was stored at 43.3, 51.5 and 71.67 °C. It was analyzed a
frequent intervals to determine the % of drug remaining and the results are given in the
below table. The product becomes ineffective when 20% of the drug gets degraded
Determine the shelf life of the product by accelerated stability testing method.
S.NO
Temperature, C
% of drug remaining after time in months
3
4.
6.
10
1
43.30
100
79.43
63.1
31.62
2HHT-
----
---.
51.50
100
66.06
44.66
29.51
13.18
-HR
----
71.67
100
54.95
30.19
16.59
9.25
Transcribed Image Text:23 Problem : A liquid oral of drug 'x' was stored at 43.3, 51.5 and 71.67 °C. It was analyzed a frequent intervals to determine the % of drug remaining and the results are given in the below table. The product becomes ineffective when 20% of the drug gets degraded Determine the shelf life of the product by accelerated stability testing method. S.NO Temperature, C % of drug remaining after time in months 3 4. 6. 10 1 43.30 100 79.43 63.1 31.62 2HHT- ---- ---. 51.50 100 66.06 44.66 29.51 13.18 -HR ---- 71.67 100 54.95 30.19 16.59 9.25
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