Promoter 5' UTR Coding region Transcription start site 5'-TACCCAGATAATATATACGCATGACACATATGGACACCGATTATAAAGATATCTACTGCCGCGAGAATTATAG-3' 3' UTR Translation start codon Translation stop codon For each DNA sequence below, there is a single nucleotide mutation in the DNA sequence. For all examples, the mutation is highlighted in orange. A codon table is provided on the second page for your reference. Answer each of the following questions for EACH DNA sequence: A) what type of mutation is shown based on the nature of the genetic change (frameshift mutation or point mutation; if a point mutation, transition or transversion) B) what type of mutation is shown based on the functional impact on the organism (frameshift, silent, missense, nonsense, noncoding) C) What do you predict the effect of that mutation will be on either the structure or function of a protein, or on the phenotype of the organism. Explain your answer. For this part, there are some examples where you should know exactly the effect of the mutation, and some where you may have to infer this information based on the location of the mutation.

Promoter 5' UTR Coding region Transcription start site 5'-TACCCAGATAATATATACGCATGACACATATGGACACCGATTATAAAGATATCTACTGCCGCGAGAATTATAG-3' 3' UTR Translation start codon Translation stop codon For each DNA sequence below, there is a single nucleotide mutation in the DNA sequence. For all examples, the mutation is highlighted in orange. A codon table is provided on the second page for your reference. Answer each of the following questions for EACH DNA sequence: A) what type of mutation is shown based on the nature of the genetic change (frameshift mutation or point mutation; if a point mutation, transition or transversion) B) what type of mutation is shown based on the functional impact on the organism (frameshift, silent, missense, nonsense, noncoding) C) What do you predict the effect of that mutation will be on either the structure or function of a protein, or on the phenotype of the organism. Explain your answer. For this part, there are some examples where you should know exactly the effect of the mutation, and some where you may have to infer this information based on the location of the mutation.

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter11: Genome Alterations: Mutation And Epigenetics

Section: Chapter Questions

Problem 10QP: If the coding region of a gene (the exons) contains 2,100 base pairs of DNA, would a missense...

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