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Q. 6.
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- Present the comparison of clinical benefit of statins and fibrates in the management of patients with atherosclerosis.Explain the role of cholesterol and lipoproteins in thedevelopment of atheromas.Discuss the risk factors for, the pathogenesis of, and the consequences of, coronaryartery atherosclerosis and comment on the possible causes and the subsequentpathologic findings that could occur with a total serum cholesterol of 268 mg/dl.
- Name the 3 broad disorders associated with the process of atherosclerosis and briefly describe the manifestations.Name and explain the mechanism of action of the anticoagulants: calcium chelators (oxalate, citrate, EDTA, fluoride), warfarin, and heparin.Distinguish between arterial (white) and venous (red) clots in terms of composition and sites of formation. Know which anticoagulants would be used to treat each.Explain three ways of reducing the risk of atherosclerosis.
- Describe the aetiopathogenesis of thrombus and state in detail the complications ofthrombus, also mention the various types and describe the systemic fate of a thrombus.The pathophysiology of a DVT (Deep Vein Thrombosis) and how it might result in a PE (Pulmonary Embolism) are explained?Differentiate vasculogenesis from angiogenesis. Explain why blood vessels degenerate as well as the significance of this degeneration.
