Q7: In the presence of Voxelotor would you expect the affinity of HbS for O2 to increase or decrease? Q8: How would you classify the mechanism of action for Voxelotor?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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The doctor also mentioned a new treatment for Sickle Cell Disease to JJ called Voxelotor
(Oxbryta). Voxelotor binds to the a-globin chain and alters the structure of HbS stabilizing it in
the R-state (relaxed state).
Q7: In the presence of Voxelotor would you expect the affinity of HbS for O2 to increase or
decrease?
Q8: How would you classify the mechanism of action for Voxelotor?
Transcribed Image Text:The doctor also mentioned a new treatment for Sickle Cell Disease to JJ called Voxelotor (Oxbryta). Voxelotor binds to the a-globin chain and alters the structure of HbS stabilizing it in the R-state (relaxed state). Q7: In the presence of Voxelotor would you expect the affinity of HbS for O2 to increase or decrease? Q8: How would you classify the mechanism of action for Voxelotor?
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