Question #1Cytotoxic granules released from cytotoxic T cells contain proteins that enter target cells and induce apoptosis. Do any of the mechanisms of apoptosis induction by cytotoxic effector T cells rely on the protein APAF-1? If so, which pathway? Question #2Cytotoxic T cells are rapid killers of infected target cells. Within minutes of the interaction of a cytotoxic T cell with a target cell, the program of apoptosis in the target cell is initiated. This rapid activity is a consequence of:The expression and packaging of perforin and granzymes in cytotoxic granules prior to target cell encounterThe extremely rapid production of granzymes and perforin by cytotoxic effector cells upon encountering a target cellThe extremely potent activity of perforins in poking holes in target cell membranes allowing entry of granzymesThe efficient activity of granzymes in cleaving effector caspases leading to direct activation of apoptosisThe large number of cytotoxic granules made and secreted by a single effector cytotoxic T cell

The essential role of cytotoxic T cells in limiting such infections is seen within the increased…

Answered: Question #1 Cytotoxic granules…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Question #1

Cytotoxic granules released from cytotoxic T cells contain proteins that enter target cells and induce apoptosis. Do any of the mechanisms of apoptosis induction by cytotoxic effector T cells rely on the protein APAF-1? If so, which pathway?

Question #2

Cytotoxic T cells are rapid killers of infected target cells. Within minutes of the interaction of a cytotoxic T cell with a target cell, the program of apoptosis in the target cell is initiated. This rapid activity is a consequence of:

The expression and packaging of perforin and granzymes in cytotoxic granules prior to target cell encounter
The extremely rapid production of granzymes and perforin by cytotoxic effector cells upon encountering a target cell
The extremely potent activity of perforins in poking holes in target cell membranes allowing entry of granzymes
The efficient activity of granzymes in cleaving effector caspases leading to direct activation of apoptosis
The large number of cytotoxic granules made and secreted by a single effector cytotoxic T cell

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