Question 25 Listen A drug that inhibits DNA methylation will a) Decrease splicing of methylated genes b) Increase transcription of methylated genes c) Increase splicing of methylated genes d) Decrease transcription of methylated genes
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25
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- which will cause a frameshift mutation?Question 26 What is true for CpG Islands: Question 26 options: stretches of a few hundred base pairs of DNA where cytosines are unmethylated are not associated with genes are not found around the promoters are associated with silenced genes Question 27 Depurination is a type of: Question 27 options: Oxidative DNA damage Hydrolytic DNA damage Aberrant DNA methylation Aberrant DNA acetylation Question 28 Methylation of DNA is normally a repressive signal Question 28 options: True FalseWhat are the Okazaki fragments?
- QUESTION NO. 1 Base excision repair A. is used only for bases that have been deaminated. B. uses enzymes called DNA glycosylases to generate an abasic sugar site. C. removes about 10 to 15 nucleotides. D. does not require an endonuclease. E. recognizes a bulky lesion. QUESTION NO. 2 Termination of a prokaryotic transcriptA. is a random process. B. requires the presence of the rho subunit of the holoenzyme. C. does not require rho factor if the end of the gene contains a G-C rich palindrome. D. is most efficient if there is an A-T-rich segment at the end of the gene. E. requires an ATPase in addition to rho factor. QUESTION NO. 3 Eukaryotic transcription A. is independent of the presence of upstream consensus sequences. B. may involve a promoter located within the region transcribed rather than upstream. C. requires a separate promoter region for each of the three ribosomal RNAs transcribed. D. requires that…What is an insertion mutation?How was the genetic code deciphered?
- Question. Rewrite the following sentences after correction. (Subject: Biotechnology) The variation in the length of tandem repeat of microsatellite DNA has serious translational affects as this is due to its coding region. Correct: If one parent has sickle cell anemia and other has carrier genotype than there is 25 % chance that any offspring is carrier. Correct: Sickled WBC block the flow of blood and Calcium as they stick together and caused by frame shift mutation. Correct: The N1303K mutation in the CFTR gene of CF patients is autosomal dominant disorder due to insertion of asparagine at 1303. Correct: If a person RBCs have B surface antigen and it will clump with antigen B such clumping indicates Blood type B. Correct: Indirect ELISA can detect polygenic gene expression. Correct:What is a temperature sensitive mutation?Briefly explain the frameshift mutation ?
