Rank the following nucleophiles correctly arranged with respect to increasing nucleophilicity in SN2 reactions. (weakest to strongest) H2O CH;NH, || CH;CO HC=C: (A) (В) (C) (D) A) A
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- Rank the nucleophiles in following group in order of increasing nucleophilicity. H2O, −OH, CH3CO2-Rank the species below in order of increasing nucleophilicity in protic solvent. I. H2O II. CH3S— III. CH3COO— IV. t-BuO— I, II, IV, III I, III, II, IV I, III, IV, II I, II, III, IVWhen drawing organic chemistry mechanisms with NaOCH3, do we automatically dissociate it into Na+ and OCH3-, making it easier to go through SN2 and/or E2 reactions? Does NaOCH3 dissociate, and is this why it is a strong nucleophile?
- Friedel–Crafts alkylation of benzene with (R)-2-chlorobutane and AlCl3 affords sec-butylbenzene.a. How many stereogenic centers are present in the product?b. Would you expect the product to exhibit optical activity? Explain, with reference to the mechanism.Rank the following in increasing order of reactivity towards nucleophilic acyl substitutiona. CH3COCl, CH3COOCH3, CH3CONH2b. CH3COOCH3, CH3COOCH2CCl3, CH3COOCH(CF)3Rank the anions in order of increasing nucleophilicity in acetone: CH3S−, CH3NH−, I−, Br−, and CH3O−.
- List the following in increasing order of nucleophilic strength. CH3COO-, H2O, CH3O-, OH-, CH3CH20-The above reaction involves heterolytic bond breakage of HBr a) Encircle the nucleophile (s) and electrophile (s) and explain why. b) Give the mechanism of the reaction by: ) Drawing the appropriate arrows to track the flow of electrons in Showing the species formed after bond breakage and bond formation with appropriate charges. c) Predict the final products.Draw the SNl or SN2 reaction with CN for the following molecules t butylchloride , n - butylbromide , 2 -bromobutane . Explain in which mechanism it will react and why ?
- Draw a detailed mechanism for the FeBr3@catalyzed reaction of ethylbenzene with bromine, and show why the sigma complex (and the transition state leading to it) is lower in energy for substitution at the ortho and para positions than it is for substitution at the meta position.Arrange the following alkyl halides in increasing reactivity in E2 reaction. Write 1 for the least reactive, then 2 and 3 for the most reactive Answer: A. _____ B. _____ C. _____Give the process of Determining the Mechanism and Stereochemistry inNucleophilic Substitution ?