Reaction of the following ketone with LiAlH4 gives two diastereomeric alcohols. Consider if nucleophilic approach would be hindered from either the top or bottom face, and then provide stereochemical descriptors for the major product. 2 3 1 4

Reaction of the following ketone with LiAlH4 gives two diastereomeric alcohols. Consider if nucleophilic approach would be hindered from either the top or bottom face, and then provide stereochemical descriptors for the major product. 2 3 1 4

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter22: Carbonyl Alpha-substitution Reactions

Section22.SE: Something Extra

Problem 20MP

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Reaction of the following ketone with LiAlH4 gives two diastereomeric
alcohols. Consider if nucleophilic approach would be hindered from either
the top or bottom face, and then provide stereochemical descriptors for
the major product.
2
3
1
4

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