regulation of receptors: homologous and heterologous receptor desensitization, receptor internalization and trafficking, receptor down-regulation
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Can you please explain me the following: regulation of receptors: homologous and heterologous receptor desensitization, receptor internalization and trafficking, receptor down-regulation
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- Which of the following would inhibit the activity of TGF-Beta receptor? multiple answers A. Deletion of Extracellular domain B. Tyrosine Kinase Inhibitor C. Mutation that prevents homodimerization of Type II Receptor D. Mutation of phosphorylation site on Type I receptor E. Inhibition Type II receptor binding to Type I receptorWhich of the following receptor types is NOT a membrane receptor? a. Channel-linked receptor b. Enzymatic receptor c. G protein–coupled receptor d. Steroid hormone receptorsYou can choose one or more than one option The dissociation constant (Kd) of a receptor is: the concentration of a ligand that produces 100% occupancy of the receptor the concentration of a ligand that produces 50% of the maximal effect. the measurement of specificity between ligand and its receptor. the measurement of speed by which a ligand will dissociate from its receptor. the measurement of affinity between a ligand and its receptor and the inverse of the association constant.
- Hello, could you please help me with the following about NICOTINE: Cell signaling pathway involved: Signal mechanism (What is the ligand?) Type of receptor: Basics of signal transduction pathway: Specifics of cellular response and organismal response:The transforming growth factory beta (TGF-b) family of hormones / growth factors are dimers and they interact with specific receptors. Which of the following statements about these receptors is correct? a) A receptor complex is formed from a type 1 and a type 2 receptor b) A receptor complex is formed between the ligand and the receptor c) This family interacts with a single serine- threonine kinase receptor d) The major receptor is intracellular e) The receptor is a G-protein receptorreceptors can be divided into for catagories on the basis of their associated mechanisms of signal transduction list them
- There are different types of functional receptors, describe one of them.what is an evolutionarily conserved class of receptor, consisting of an integral membrane receptor protein coupled to an intracellular protein that transmits signals to the interior of the cell.Which of the following statements most accurately describes what happens when an antagonist binds to a receptor? The antagonist binds non-covalently to the receptor and promotes internalisation of the receptor. Antagonist binding alters the structure of the receptor making it unable to function normally. At sufficiently high concentrations the antagonist can prevent the receptor from binding to its natural (endogenous) ligand. The antagonist-receptor complex binds to a heterotrimeric G protein forming a stable and inactive ternary complex.
- Nerve growth factor binds to which type of receptor? a.) Receptor tyrosine phosphatases b.) Receptor Serine/Threonine Kinase c.) Receptor guanylyl cyclase d.) Receptor tyrosine kinaseWhich of the following best describes the type of receptor a beta-antagonist drugs acts on a.Ligand-regulated transmembrane enzymes b.Ion channel c.G protein-coupled receptor d.Intracellular lipid-soluble signalingName three features common to the activation of cytokine receptors and receptor tyrosine kinases. Name one difference with respect to the enzyme activity of these receptors.