PLEASE DRAW YOUR REASONING. ALSO, EXPLAIN WHY YOUR ANSWER IS CORRECT AND NOT THE OTHERS. Kaitlyn's doctor cautions her against taking baths in Epsom salts (MgSO4), or from takingmagnesium nutritional supplements, because the magnesium can block voltage-gated calciumchannels.8. Where are these channels found?a. In the dendrites of the somatic motor neuronb.In the presynaptic terminal of the somatic motor neuronc. In the sarcolemma of the muscle cellsd.In the t-tubules of the muscle cells Goal: Apply concepts about the afferent and efferent branches of the nervous system to a casestudy on myasthenia gravis.Context: Myasthenia gravis (literally 'severe muscle weakness') is an autoimmune disease, inwhich the body's immune system attacks parts of the body. In myasthenia gravis the immunesystem begins attacking the nicotinic acetylcholine receptor (nAChR). It is the most commondisorder of neuromuscular transmission, and is more common in women than men, as is truefor most autoimmune diseases. Women are typically affected between the ages of 20-40 years;in men it is most generally found after age 60.The nACHR is pentameric, meaning it is comprised of five subunits. Thesesubunits vary in structure producing at least 17 different subtypes(isoforms) of nAChR that vary in their structure and function. There aremuscle-specific isoforms found only in skeletal muscle, CNS-specificisoforms, autonomic-specific isoforms - including isoforms only found inparasympathetic or sympathetic neurons, etc.). Typically myastheniagravis affects skeletal muscle, particularly cranial muscles, but in someindividuals the autonomic nervous system may also be affected. Thisdepends upon which subunit(s) are targeted by the immune system and consequently whichchannel isoforms are impacted.Scenario: Kaitlyn is a 28-year-old nutritionist who visits herfamily doctor complaining of muscle weakness and fatigability,some difficulty swallowing (dysphagia) and slurred speech(dysarthria). Upon examination, Jane's doctor also observedptosis (eyelid drooping) on the left side.ACHcell membraneKaitlyn's doctor suspects myasthenia gravis and orders blood tests to look for the presence ofnACHR antibodies, an MRI to look for tumors in the thymus (~75% of patients have a thymusabnormality), and a nerve stimulation test to look for evidence of changes in neuromusculartransmission.

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Acetylcholine is a neurotransmitter that serves both excitatory and inhibitory functions. It has…