A series of monoamine oxidase inhibitors were synthesised and the following Hanschequation was derived.N.Log (-) = 0.39n – 0.120 + 1.03ES + 4.541What substituents (R) would you introduce to enhance bioactivity andwhy?(iii) What effect would introducing an electron donating group have onbioactivity?(ii)

Log1/C = Measure of Biological activity

Answered: se inhibitors were s

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se inhibitors were s

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter17: Carboxylic Acids

Section17.9: Decarboxylation

Problem 17.6P

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Question

A series of monoamine oxidase inhibitors were synthesised and the following Hansch
equation was derived.
N.
Log (-) = 0.39n – 0.120 + 1.03ES + 4.541
What substituents (R) would you introduce to enhance bioactivity and
why?
(iii) What effect would introducing an electron donating group have on
bioactivity?
(ii)

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