Select the correct statement -collective cell migration helps in wound healing, but is also involved in cancer invasion and spreading -The tunnel assay for cell death involves labeling of intact DNA before double strands occur -during cleavage dividing cells go through G1, S, G2, and M phases -at the cleavage stage the transcription of the cyclinB mRNA is active.

Select the correct statement -collective cell migration helps in wound healing, but is also involved in cancer invasion and spreading -The tunnel assay for cell death involves labeling of intact DNA before double strands occur -during cleavage dividing cells go through G1, S, G2, and M phases -at the cleavage stage the transcription of the cyclinB mRNA is active.

Biology: The Dynamic Science (MindTap Course List)

4th Edition

ISBN:9781305389892

Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Chapter10: Cell Division And Mitosis

Section: Chapter Questions

Problem 1ITD: Biologists have long been interested in the effects of radiation on cells. In one experiment,...

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Cell division cycle (cdc) mutations identify genes, the normal products of which are.. required at a particular phase of the cell cycle. expressed at a particular phase of the cell cycle. inactive at high temperatures. active at high temperatures. involved in DNA synthesis.
Wire Models for Cell Division 1. Mitosis Label the chromosomes at metaphase. Identify the types of chromosomes in the genome. Give the chromosome number (in proper format) and chromosome composition of the cell.
VISUALIZE Sketch a roughly cuboidal cell preparing to divide. Indicate the orientation of the preprophase band and the site where the new cell walls of the daughter cells will form.
Discuss the complete cell cycle in a human cell, mitosis and meiosis, and the regulatory components (i.e. the proteins associated with cellular checkpoints) of the cell cycle. Tumor growth results when the cell cycle checkpoints are ignored. Give an example of how tumor growth could result from either a loss-of-function or a gain-of-function mutation.
Relate histopath criteria of cancer to H nana cell cycle & chromosomal instability. Analyze the image attached and discuss how many of the mutations in cancer affect the normal regulation of the cell cycle, particularly the G2 checkpoint where mutations are supposed to be caught and not passed on. If there's a mutation in this checkpoint - notably p53 - then mutations are passed on and accumulate and we see bizarre chromosomes in cancer. Refer to original question to discuss how the histopathy criteria of cancer (unifrom population of pleimorphic cells, variable cytoplasmic nuclear ratio, multiple/bizarre nucleoli and frequent/bizarre mitotic figures) these relate to H nana cell cycle and chromosomal instability.
In your own words: Describe the molecular mechanisms involved in P53’s role as a tumor repressor protein.
You are looking at the results of a western blot from the lysates of cells harvested from a suspected breast cancer tumor and you see that there is an increased expression of INK4-p16, you suspect that this will______________? Group of answer choices Increase S to G2 phase transition Initiate a cell cycle arrest in G1 Block M to G1 phase transition Promote tumorigenesis
mutations in breast cancer susceptibility genes BRCA1 & 2 principally cause with ? (a) nucleotide excision repair (b) translational fidelity (c) transcriptional fidelity (d) regulation of meiotic recombination at the Holiday Junction (e) Double Strand Break repair
In your own words, explain how cancer cells differ from normal cells in regard to the following: Molecular controls of the cell cycle (include Cdk and Cdk/cyclin complexes, p53 gene/protein, Rb gene/protein in response)
Genetic instability in the form of point mutations, chromosome rearrangements, and epigenetic changes needs to be maximal to allow the development of cancer. (a) With diagrams explain, chromosome rearrangement
Disdis -how do RB and p53 negatively regulate the cell cycle in G1? describe the events that occur in the initiation and elongation of DNA replication in S phase.
1. True or Flase: Cells must only divide when they receive a signal to divide. 2. BRCA1 is a gene that codes for a tumor suppressor protein. If a person inherits a mutation in BRCA1, it greatly increases his or her risk of developing breast cancer. Are the cancer-causing mutations in the BRCA1 gene more likely to: a) increase expression of the gene b)decrease expression of the gene c)not affect the expression of the gene