Relate histopath criteria of cancer to H nana cell cycle & chromosomal instability. Analyze the image attached and discuss how many of the mutations in cancer affect the normal regulation of the cell cycle, particularly the G2 checkpoint where mutations are supposed to be caught and not passed on. If there's a mutation in this checkpoint - notably p53 - then mutations are passed on and accumulate and we see bizarre chromosomes in cancer. Refer to original question to discuss how the histopathy criteria of cancer (unifrom population of pleimorphic cells, variable cytoplasmic nuclear ratio, multiple/bizarre nucleoli and frequent/bizarre mitotic figures) these relate to H nana cell cycle and chromosomal instability.
Relate histopath criteria of cancer to H nana cell cycle & chromosomal instability. Analyze the image attached and discuss how many of the mutations in cancer affect the normal regulation of the cell cycle, particularly the G2 checkpoint where mutations are supposed to be caught and not passed on. If there's a mutation in this checkpoint - notably p53 - then mutations are passed on and accumulate and we see bizarre chromosomes in cancer. Refer to original question to discuss how the histopathy criteria of cancer (unifrom population of pleimorphic cells, variable cytoplasmic nuclear ratio, multiple/bizarre nucleoli and frequent/bizarre mitotic figures) these relate to H nana cell cycle and chromosomal instability.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Relate histopath criteria of cancer to H nana cell cycle & chromosomal instability. Analyze the image attached and discuss how many of the mutations in cancer affect the normal regulation of the cell cycle, particularly the G2 checkpoint where mutations are supposed to be caught and not passed on. If there's a mutation in this checkpoint - notably p53 - then mutations are passed on and accumulate and we see bizarre chromosomes in cancer. Refer to original question to discuss how the histopathy criteria of cancer (unifrom population of pleimorphic cells, variable cytoplasmic nuclear ratio, multiple/bizarre nucleoli and frequent/bizarre mitotic figures) these relate to H nana cell cycle and chromosomal instability.
Transcribed Image Text:Supplementary table 3. Details of insertion mutation-associated genes.
Insertion Gene name
site
H. nana
scaffold/
Contig
HNAJ_contig 9417&
0000005
9432
HNAJ_contig
0000016
Insertion
site left and
right
breakpoints
HNAJ_contig
0001786
8699&
8713
8291 &
8305
HINAL contig 38238
0003361
3827
HNAJ_scaffol 5852&
d0001194
5858
HNAJ_scaffol 1985&
d0001466
1990
nearest
predicted
exon
11944-
12600
8707-
9013
n/a
2391
2501
5383-
5512
2411-
2866
H.
microstoma
homolog
HmN_00062 87%
4000
HmN_00081 68%
0600
n/a
Amino
acid
identity
(nearest
exon)
HMN 00084 64%
6700
5100
n/a
HmN_00026 84%
0800
HmN_00056 91%
intron
intron
n/a
5(1.3 kb
from
start
codon)
intron
3'
(422bp
from
stop
codon)
serine:
threonine
protein
kinase ULK2
hypothetical
protein
n/a
TPP:
intracisternal
A particle-
promoted
polypeptide
PHF10:
PHD finger
protein 10
C2H2 type
zinc finger
Gene function
Autophagy regulation ¹5
Unknown
n/a
Actin binding protein 19
Baf45a/PHF10
Chromatin remodeling
via swi/snf complex ;
neuronal stem cell
differentiation
DNA binding; putative
transcriptional
regulation
Association with cancer
Down regulated in
glioblastoma multiforme¹7;
downstream of p53
regulated cell death18
n/a
n/a
Breast cancer in humans
and mice2¹
Colorectal cancer 23 and
gastric cancer24 25
n/a
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