Spongy bone formation in primary ossification center Removal of spongy bone to form medullary cavity Articular cartilage, which will remain throughout life to protect the ends of bones Spongy bone in the epiphysis Enlarging chondrocytes within calcifying matrix Epiphyseal cartilage, where the bone will continue to Formation of spongy bone in the secondary Bone sheath formation Formation of compact bone along the diaphysis Periosteum around shaft of cartilage elongate until adulthood ossification centers rod

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