I have attached the reaction and mechanism. So please discuss any stereochemistry issues or regioselectivity. Is there any selectivity? Or by using PPh2 there is some selectivity?? I don't understand how much simpler I can make this question as it keeps getting rejected by experts. THF, HMPA[HWE -> Diene]Oxide+Aldehyde]юH]0ОНPPh₂уOH Step 1:Step 2:(E)-(1-(diphenylphosphoryl)but-2-en-1-yl) lithiumHStep 3:HHStep 4:(S)-4-(2-(5-hydroxypentyl)-1,3-dioxolan-2-yl)-2-methylbutanalOHPPh₂_OHPPh ₂THEHMPAPPh-OHPPh₂OHHHPPh₂O_PPh₂OHO™-PPh₂OHLi+O=PPh₂H5-(2-((S,4E,6E)-3-methylocta-4,6-dien-1-yl)-1,3-dioxolan-2-yl)pentan-1-ol

The given reaction is an example of Horner–Wadsworth–Emmons (HWE) reaction.In the given reaction the…

Step 1: Step 2: (E)-(1-(diphenylphosphoryl)but-2-en- 1-yl)lithium H Step 3: H Step 4: OH (S)-4-(2-(5-hydroxypentyl)-1,3-dioxolan-2-yl)-2-methylbutanal PPh₂ OH PPh₂ THE HMPA Ph₂ _OH PPh₂ ů OH H H o PPh₂ OH PPh₂ O_ O™ PPh₂ OH Li+ O=PPh₂ H 5-(2-((S,4E,6E)-3-methylocta-4,6-dien-1-yl)-1,3-dioxolan-2-yl)pentan-1-ol

Step 1: Step 2: (E)-(1-(diphenylphosphoryl)but-2-en- 1-yl)lithium H Step 3: H Step 4: OH (S)-4-(2-(5-hydroxypentyl)-1,3-dioxolan-2-yl)-2-methylbutanal PPh₂ OH PPh₂ THE HMPA Ph₂ _OH PPh₂ ů OH H H o PPh₂ OH PPh₂ O_ O™ PPh₂ OH Li+ O=PPh₂ H 5-(2-((S,4E,6E)-3-methylocta-4,6-dien-1-yl)-1,3-dioxolan-2-yl)pentan-1-ol

EBK A SMALL SCALE APPROACH TO ORGANIC L

4th Edition

ISBN:9781305446021

Author:Lampman

Publisher:Lampman

Chapter41: 1,4-diphenyl-1,3-butadiene

Section: Chapter Questions

Problem 2Q

See similar textbooks