Question: Suggest two reasons why people had the drug injected into the cerebrospinal fluid (lines 12–13) rather than taking a pill containing the drug. Guillain-Barré syndrome is a rare disease in which the immune systemdamages the myelin sheath of neurones. Myelin sheath damage can cause arange of symptoms, for example numbness, muscular weakness and muscularparalysis. Sometimes, neurones of the autonomic nervous system areaffected, causing heart rate irregularities.Huntington's disease is a disorder caused when a protein called huntingtindamages the brain. Huntingtin is produced because of a dominant, mutantallele.The first successful drug trial to reduce concentrations of huntingtin in thehuman brain involved 46 patients. The patients received the drug for 4months. The concentration of huntingtin was reduced in all the patients.The drug was injected at the base of the spine into the cerebrospinal fluidbathing the brain and spinal cord. The drug contains single-stranded DNAmolecules. These single-stranded molecules inhibit the MRNA needed toproduce huntingtin.1015Symptoms of Huntington's disease can start at any time, but usually developbetween 30 and 50 years of age. The likelihood and age when symptoms startare linked to the number of CAG base sequence repeats in the gene forHuntington's disease. However, recent studies have suggested thatepigenetics may also affect the age when symptoms first start.20

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Suggest two reasons why people had the drug injected into the cerebrospinal fluid (lines 12–13) rather than taking a pill containing the drug

Human Biology (MindTap Course List)

11th Edition

ISBN:9781305112100

Author:Cecie Starr, Beverly McMillan

Publisher:Cecie Starr, Beverly McMillan

Chapter22: Genes And Disease: Cancer

Section: Chapter Questions

Problem 3SQ

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