Suppose that you are studying the role of Protein B, which you believe plays a role in regulating PCD/Apoptosis in mice. You create two lines of mutant mice. One (bb) is homozygous for a loss-of-function allele of gene B. The other (Bb) is heterozygous, with one wild-type allele and one loss-of function allele. Initially you pay particular attention to two phenotypes of the resulting mice:(i) The morphology of their paws (see picture)(ii) The size of their brains & shape of their skulls. The bb mice have unusually large brains and unusual protrusions from their skulls. Suggest one other aspect of mouse morphology or physiology that you might expect to be altered in the absence of Protein B. Briefly explain your reasoning. Also, based on the apparent effect of Protein B on the likelihood of PCD/Apoptosis, would you classify Protein B as the product of a proto-oncogene or of a tumor suppressor gene?
Suppose that you are studying the role of Protein B, which you believe plays a role in regulating PCD/Apoptosis in mice. You create two lines of mutant mice. One (bb) is homozygous for a loss-of-function allele of gene B. The other (Bb) is heterozygous, with one wild-type allele and one loss-of function allele. Initially you pay particular attention to two
Suggest one other aspect of mouse morphology or physiology that you might expect to be altered in the absence of Protein B. Briefly explain your reasoning.
Also, based on the apparent effect of Protein B on the likelihood of PCD/Apoptosis, would you classify Protein B as the product of a proto-oncogene or of a tumor suppressor gene?
Trending now
This is a popular solution!
Step by step
Solved in 3 steps
