The enzyme katanin, named after the Japanese samurai swords, cleaves microtubules into short pieces. What is the fate of the microtubule fragments created by katanin (would they grow or shrink)? Why?
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The enzyme katanin, named after the Japanese samurai swords, cleaves microtubules into short pieces. What is the fate of the microtubule fragments created by katanin (would they grow or shrink)? Why?
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- The drug chloral hydrate prevents elongation of microtubules by preventing the addition of new subunits to the growing end. During which stage of mitosis would chloral hydrate be most harmful?In all cells, microtubules nucleate from the centrosome and then become stabilized or collapse. What feature of microtubules contributes to this phenomenon?What is the name of the structure that the microtubules bind to during mitosis?
- Taxol is a drug that inhibits microtubule dynamics and is often used for cancer chemotherapy because it preferentially affects dividing cells. What microtubule-based structure is likely disrupted by Taxol so that it specifically affects proliferating cells?Of which substance are microtubules made? In which structures and cellular processes do microtubules participate?Tubulins bind GTP and hydrolyze it, which causes microtubules to become dynamically unstable. How does this happen?
- Microtubules both in vitro and in vivo undergo dynamic instability, and this type of assembly is thought to be intrinsic to the microtubule. What is the current model that accounts for dynamic instability?How did you know that Paclitaxel was inhibiting cell division? What method of observation was used and how did you interpret the images to come to your conclusion that Paclitaxel was inhibiting cell division?Based on the motors moving along the microtubule in the center of the field, would you propose: That a single microtubule can accommodate motors moving in both directions, or not? That all of the motors moving along a single microtubule move at the same speed, or not?
- Which of the following changes to the microtubule binding protein, Tau, commonly occurs in Alzheimerâ s and other neurodegenerative diseases? A Tau is hypo-phosphorylated and does not bind to microtubules to destabilize them. B Tau levels are so low in the cell that they only bind to some microtubules. C Tau is hyper-phosphorylated and does not bind to microtubules to stabilize them. D Microtubules are hyper-phosphorylated and do not bind to Tau.what is the difference between chromatid and chromatin?Describe one instance when the polarity of microtubules is important in cell function.