The fluids deep in the medulla of the kidney have a much highersolute concentration than those in the cortex. Where do the solutes inthe medulla come from? What is the role of that high soluteconcentration in the functioning of the nephron loop?

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The fluids deep in the medulla of the kidney have a much higher
solute concentration than those in the cortex. Where do the solutes in
the medulla come from? What is the role of that high solute
concentration in the functioning of the nephron loop?

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