The Merrifield solid phase synthesis is commercially used for the production of peptides. Identify all of the steps necessary to prepare the peptide Ala-Val-Leu-Ile with a Merrifield synthesis using DCC, Fmoc and any other readily available reagents. In your answer,

The Merrifield solid phase synthesis is commercially used for the production of peptides. Identify all of the steps necessary to prepare the peptide Ala-Val-Leu-Ile with a Merrifield synthesis using DCC, Fmoc and any other readily available reagents. In your answer,

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter26: Biomolecules: Amino Acids, Peptides, And Proteins

Section26.6: Peptide Sequencing: The Edman Degradation

Problem 13P

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Question

c) The Merrifield solid phase synthesis is commercially used for the production of peptides.
Identify all of the steps necessary to prepare the peptide Ala-Val-Leu-Ile with a Merrifield
synthesis using DCC, Fmoc and any other readily available reagents. In your answer,
include the coupling mechanism and N protection mechanism (ONLY ONCE).

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