The pedigree below shows that inheritance of a disease that is caused by a late onset, dominant, autosomal mutation that is rare, but only 50% penetrant. The gene that is mutated in the disease is linked at a distance of 10 cm to a microsatellite marker that has alleles numbered 1, 2, and 3. The marker alleles detected in each individual are indicated below. What is the probability that individual A will develop the disease? Explain using an illustration of this occurs.

Essentials of Pharmacology for Health Professions
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ISBN:9781305441620
Author:WOODROW
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Chapter5: Abbreviations And Systems Of Measurement
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The pedigree below shows that inheritance of a disease that is caused by a late onset, dominant, autosomal mutation that is rare, but only 50% penetrant. The gene that is mutated in the disease is linked at a distance of 10 cm to a microsatellite marker that has alleles numbered 1, 2, and 3. The marker alleles detected in each individual are indicated below.

What is the probability that individual A will develop the disease? Explain using an illustration of this occurs.

13
22
12
32
?
12
32
A
В
Transcribed Image Text:13 22 12 32 ? 12 32 A В
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