The pharmaceutical drug, Celecoxib, canbe made through a condensation of a substituted aryl hydrazine with a 1-3 dione shown below. Provide a mechanism for this transformation. Use any acid catalysts you may need. H₂N -2 H₂O NH₂ H₂N oo FF Celecoxib
The pharmaceutical drug, Celecoxib, canbe made through a condensation of a substituted aryl hydrazine with a 1-3 dione shown below. Provide a mechanism for this transformation. Use any acid catalysts you may need. H₂N -2 H₂O NH₂ H₂N oo FF Celecoxib
Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter11: Ethers, Epoxides, And Sulfides
Section: Chapter Questions
Problem 11.21P: Ethylene oxide is the starting material for the synthesis of 1,4-dioxane. Propose a mechanism for...
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![The pharmaceutical drug, Celecoxib, canbe made through a condensation of a substituted aryl hydrazine with
a 1-3 dione shown below. Provide a mechanism for this transformation. Use any acid catalysts you may need.
H₂N
-2 H₂O
NH₂
H₂N
Celecoxib](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fc7acdc7d-340f-42a7-93d9-7dc075f154fa%2F37f98585-d38d-4c75-8fb7-d26a9a94d475%2Fy32077o_processed.jpeg&w=3840&q=75)
Transcribed Image Text:The pharmaceutical drug, Celecoxib, canbe made through a condensation of a substituted aryl hydrazine with
a 1-3 dione shown below. Provide a mechanism for this transformation. Use any acid catalysts you may need.
H₂N
-2 H₂O
NH₂
H₂N
Celecoxib
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