The plate below is a test of 7 different antibiotics against Enterobacter aerogenes. The center disc is Ciprofloxacin 15 micrograms) and the 24 hour extent of the Zone of Inhibition is the farther diameter. The one below it and slightly to the right is Chloramphenicol (30 micrograms) [see red arrow}. Give me the extent of the Zone of Inhibition in mm (yes, use a ruler and measure it at the size it comes up on your computer screen), then use the Standard Table and determine R, I, S for each.

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Chapter5: The Cardiovascular Sytem
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The plate below is a test of 7 different antibiotics against Enterobacter aerogenes. The center disc is Ciprofloxacin 15 micrograms) and the 24 hour extent of the Zone of Inhibition is the farther diameter. The one below it and slightly to the right is Chloramphenicol (30 micrograms) [see red arrow}. Give me the extent of the Zone of Inhibition in mm (yes, use a ruler and measure it at the size it comes up on your computer screen), then use the Standard Table and determine R, I, S for each.

Antibiotic

Zone of Inhibition (mm)

R, I or S

Drug target

Ciprofloxacin

 

 

 

Chloramphenicol

 

 

 

Which of the 2 drugs is more selective and why?

 

VA2
Transcribed Image Text:VA2
Inhibitory zone diameter to nearest millimeter (mm)
Name of antibiotics (dose)
Moderately sensitive
Sensitive (S)
Resistant (R)
(MS)
Amoxicillin (30µg/disk)
Cloxacillin (5 µg/disk)
Cephalothin (30 µg/disk)
218
14–17
<13
225
22–24
S21
218
15–17
S14
Cephradine (25 µg/disk)
Cefuroxime (30µg/disk)
Cefixime (5 µg/disk)
218
13–17
s12
223
15–22
S14
219
16–18
s15
Kanamycin (30 µug/disk)
Streptomycin (10µg/disk)
Neomycin (30 µg/disk)
Vancomycin (30 µg/disk)
218
14–17
s13
215
12–14
<11
217
13–16
s12
212
10–11
Erythromycin (15 µg/disk)
Azithromycin (15 µg/disk)
Ciprofloxacin (15 µg/disk)
Levofloxacin (5 µg/disk)
223
14–22
s13
218
14–17
s13
221
16–20
s15
217
14–16
s13
Tetracycline (30 µg/disk)
215
12–14
s11
Doxycycline (30 µg/disk)
214
11-13
s10
Cotrimoxazole (25 µg/disk)
216
11-15
s10
Chloramphenicol (30 µg/disk)
218
13–17
<12
Transcribed Image Text:Inhibitory zone diameter to nearest millimeter (mm) Name of antibiotics (dose) Moderately sensitive Sensitive (S) Resistant (R) (MS) Amoxicillin (30µg/disk) Cloxacillin (5 µg/disk) Cephalothin (30 µg/disk) 218 14–17 <13 225 22–24 S21 218 15–17 S14 Cephradine (25 µg/disk) Cefuroxime (30µg/disk) Cefixime (5 µg/disk) 218 13–17 s12 223 15–22 S14 219 16–18 s15 Kanamycin (30 µug/disk) Streptomycin (10µg/disk) Neomycin (30 µg/disk) Vancomycin (30 µg/disk) 218 14–17 s13 215 12–14 <11 217 13–16 s12 212 10–11 Erythromycin (15 µg/disk) Azithromycin (15 µg/disk) Ciprofloxacin (15 µg/disk) Levofloxacin (5 µg/disk) 223 14–22 s13 218 14–17 s13 221 16–20 s15 217 14–16 s13 Tetracycline (30 µg/disk) 215 12–14 s11 Doxycycline (30 µg/disk) 214 11-13 s10 Cotrimoxazole (25 µg/disk) 216 11-15 s10 Chloramphenicol (30 µg/disk) 218 13–17 <12
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