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Methadone elimination has very large patient to patient variability. A slow
1. 2.5 days
2. 6.5 days
3 4.5 days
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- A 35 year old woman begins therapy with a drug( 50 mg twice daily) that has a volume distribution of 70L and an elimination half life of 2 days. According to first order kineticds, the average drug concentration will reach 75% of the average steady state blood concentration after how many days (A) 2 (B) 4 (C) 6 (D) 8 (E) 10A patient is prescribed venlafaxine 75mg daily for 7 days, increasing by 75mg daily every week until a maximum daily dose of 375mg is reached. A total of 6 weeks treatment must be dispensed. You supply your total stock of 56 venlafaxine 75mg tablets. How many boxes of 28 tablets are still owed to the patient? unit- boxesWhich type of inhibitor causes an apparent increase in Vmax? Question 2 options: Uncompetitive Irreversible None of these options Competitive
- Megadoses of antioxidants are a great way to catch up on deficiencies, and since they are natural, they have no harmful side effects. true or falsevitamin e is a proven antioxidant and may help in fighting cancer and heart disease is the statement reasonable why or why not?A 250 mg per L solution of drug is administered intravenously at a rate of 40 mL per hr to a patient with constant blood volume equal to 5 L. The drug is metabolized by the patient at a rate of 30 % per hr. Assuming the patient had no drug in their system before receiving treatment, how much is found in their system after 55 minutes? Answer BLANK mg (accuracy to at least four decimal places is required so do not round carelessly).
- Drug A has a toxic dose of 50 g/kg of body weight and a therapeutic dose of 5 g/kg of body weight. Drug B has a toxic dose of 8 g/kg of body weight and a therapeutic dose of 4 g/kg of body weight. Which Drug has a higher chemotherapeutic index? A: Drug A B: Drug BExplain the role of different toxicological parameters (i.e. ED50, TD50, LD50, NOAEL, LOAEL, etc.) in ensuring the safety of a drug candidate. explain this in 600-1000 words,please explain at your own wordsDescription of clinical trial process for the Pfizer-BioNTech. Incorporate the following key words: Length of trial; population diversity; efficacy; side effects Pfizer-BioNTech
- The dose of a chemotherapeutic agent prescribed for a patient who weighs 150 lbs. and is 5’1” tall is 1500 mg/m2/dose given once. The body surface area of the patient is ________ m2, and each dose is equivalent to ______g.In the double-reciprocal plot, increasing the concentration of inhibitor A. raises the Vmax. B. lowers the Km / Vmax. C. raises the Km / Vmax. D. lowers the Km.Drug A has the concentrations indicated below in the blood following intravenous administration. From these data calculate the half-life (t1/2) of Drug A is: Drug A Concentrations Time After Intravenous Administration μg/mL of drug A in blood 2 hours 100 6 hours 25 10 hours 6.25 14 hours 1.56