Using the new cardiovascular drug Entresto, relate how the Cardiac action potential arriving at the surface of the sarcolema results in the mobilisation of intracellular calcium and subsequent cellular contraction.
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Using the new cardiovascular drug Entresto, relate how the Cardiac action potential arriving at the surface of the sarcolema results in the mobilisation of intracellular calcium and subsequent cellular contraction.
List the references used to get the answer
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- Explain the concept of tetany in skeletal muscle. Can cardiac muscle be tetanized? Explain the physiological significance of your answer.Draw a ventricular muscle cell action potential in the figure below.Briefly describe the changes in membrane permeability that underlie the potential changes.Describe the structure of intercalated discs in cardiac musclecells, and briefly discuss their functions.
- Explain in details contraction of the heart on cellular level by describing the contraction of an individual muscle fiber.Explain the structure of cardiac muscle and how it helps produce coordinated contraction in each heart chamber.Explain differences between action potentials of cardiac muscle cells and those in nodal cells of the conducting system
- The movement of which two ions is responsible for maintaining the plateau phase of the action potential of contractile cardiac muscle cells? Select one: a. Ca2+ and Na+ b. Ca2+ and K+ c. Na+ and Cl- d. Na+ and K+ e. K+ and Cl-What is the role of Ca2+ in the shape and duration of an action potential. (Cardiac muscle cell)Which of the following statements best describes the differences in the regulation of cardiac and skeletal muscle contraction? The amount of contractile force actively generated by muscle cells is increased by stretch in skeletal muscle and decreased by stretch in cardiac muscle. Cardiac muscle is stimulated by motor neurons and skeletal muscle by neurones from the autonomic nervous system. Skeletal muscle contractile force is augmented by increasing the firing frequency of action potentials whereas cardiac muscle contractile force is enhanced by noradrenaline increasing calcium influx through ion channels. Ryanodine receptors in skeletal muscle are opened by a mechanism that requires calcium influx whereas in cardiac muscle membrane depolarisation alone without calcium influx is sufficient to open ryanodine receptors.
- The role of calcium currents in cardiac contractile cells is to . The role of calcium currents in cardiac conductive cells is to . Choose between: release neurotransmitter, bring the membrane potential to threshold, initiate action potential, prolong action potential, terminate action potentialIn a patient given a cardiac glycoside, important effects of the drug on the heart include which of the following? a) Increased force of contraction. b)Decreased atrioventricular conduction velocity c)Decreased ejection time d)Increased ectopic automaticityAll of the aboveDiagram electrical conduction of the heart and discuss each component (SA node, AV node, etc). How does this dictate the fluidity of heart contraction? Why does the SA always start the conduction? What is the inherent rate of depolarization of the SA node (this means that if the nervous system was shut off what would resting bpm be)? If it is damaged what happens to the electrical conduction system?
