Asked Apr 5, 2019

What are the advantages and disadvantages to semisynthetic penicillins?

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Step 1

Antibiotics are antimicrobial substances that control or inhibit the growth of microorganisms, particularly the bacteria. Penicillin is one of the first antibiotics used to treat bacterial infections and due to its extensive usage several bacteria have developed resistance for it. Due to the several adverse disadvantages of using natural penicillin the requirement to develop semisynthetic penicillins arose.


There are four types of semisynthetic penicillins:

  • Acid-resistant penicillins
  • Extended spectrum penicillins
  • Penicillinase resistant penicillins
  • Reverse spectrum penicillins
Step 2

The following are the advantages of using semisynthetic penicillins:

  • Relatively nontoxic
  • Affects even the sensitive strains
  • Cost effective
  • Some are resistant to stomach acids
  • High tissue penetration
  • Highly effective


The following are the disadvantages of using semisynthetic penicillins:

  • Duration of action is less
  • Affects the gastrointestinal tract and causes pain and inflammation
  • Intramuscular administratio...

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