What does the AST/ALT ratio indicate for this patient  What if your AST/ALT ratio were >1. What would that suggest?

Principles Of Pharmacology Med Assist
6th Edition
ISBN:9781337512442
Author:RICE
Publisher:RICE
Chapter11: Administration Of Nonparenteral Medications
Section: Chapter Questions
Problem 21RQ
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A 32 yr old female presented to your office complaining of abdominal pain. She states this pain started yesterday and increased over the course of a couple of hours. It is mostly in the epigastric region and does radiate at times to the RUQ. She states it has been constant since then. Currently rates it at a 7/10. She has never had pain like this before. Denies any vomiting but does complain of nausea. She denies any diarrhea or constipation. Denies any documented fevers but has felt a little chilled this am. Denies any abdominal bloating. She does state she drinks a glass of wine each evening. Denies any tobacco use or street drug use.

Current labs WBC 13.2 Hgb 14.0 Hct 38.9

Plt 250

Na 142
K 4.0
BUN 26
CR 1.2
Total bilirubin 2.5 mg/dl AST 289

ALT 302
Alk Phos 358

  1. What does the AST/ALT ratio indicate for this patient 
  2. What if your AST/ALT ratio were >1. What would that suggest?
Expert Solution
Step 1

AST (Aspartate aminotransferase) and ALT (Alanine transaminase) are two enzymes of the liver that are released into the bloodstream on damage to liver cells. 

 

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