Q: List five types of cancer in which ncRNAs can be involved.
A: Non-coding RNA (ncRNA) is an RNA molecule that is not translated into a protein. Epigenetic related…
Q: What are RNA polymeraseIII in transcription in eukaryotes?
A: The central dogma of molecular biology explains the flow of genetic information through the…
Q: What is meant by the term transcription factor modulation? List three general ways this can occur.
A: Transcription is the first step in central dogma of protein synthesis process. The conserved part in…
Q: How does C-terminal domain of RNA polymerase II function to ensure that the varoius sets of mRNA…
A: RNA polymerase II is a multiprotein complex that transcribes DNA into precursors of mRNA and…
Q: What is the difference between an miRNA and an siRNA. How dothese ncRNAs affect mRNAs?
A: Ribonucleic acid or RNA is a polymeric molecule of nucleic acid which is essential in various…
Q: GW155060 is a gene whose mRNA is increased by PPAR-delta
A: GW155060 is a gene that was identified from the organism Amphimedon queenslandica a decade ago. The…
Q: Why Cas9 requires a single guide RNA (sgRNA) ?
A: The RNA guide is mainly transcribed from the intergenic DNA maxicircle region and complements mature…
Q: What part of the E.coli RNA polymerase specifically binds to the -10 and -35 region of an E.coli…
A: The RNA (ribonucleic acid) polymerase of Escherichia coli has 6 six subunits. The various subunits…
Q: Do you think it would be easier to mutate the GR receptor or treat someone with a miRNA to overcome…
A: MicroRNAs are a grade of non-coding RNAs which plays vital role in managing gene expression. Large…
Q: How Linker scanning mutations identify transcription control elements. ?
A: The regulation of gene expression is dependent on many factors. The promoter is the upstream…
Q: What do promoters do in Bacteria? How is atranscript in Bacteria terminated?
A: A structure of mRNA is generated when an unpaired mRNA strand folds and base pairs with another part…
Q: What are RNA polymeraseII in transcription in eukaryotes?
A: RNA polymerase {or the DNA dependent RNA polymerase} was discovered by Weiss and Hurwitz in the year…
Q: Let’s suppose that the overexpression of a particular miRNA was associatedwith pancreatic cancer.…
A: Answer is b.) A DNA -demethylating agent .
Q: In a normal cell, micro-RNA (mIR-433) acts to regulate ras - what would happen to a cell if there…
A: Normal DNA contains a particular sequence of DNA. If the sequence of DNA is changed due to external…
Q: What do the promoters of nearly all eukaryotic genes contain?
A: Promoter is a region in a gene where enhancer binds and transcription of gene starts. TATA…
Q: How can a tRNA be engineered to encode for a syntheticamino acid?
A: The standard genetic code features 20 natural amino acids which are the units of proteins. They are…
Q: which enzyme is used in the processing of miRNAs that are encoded in the genome but not in the…
A: Introduction Short interfering RNA or siRNA along with miRNA with DICER enzyme form the silencing…
Q: Why are histone modifying enzymes important?
A: Chromosomes are thread-like structures that are present in the nucleus of the cell. The basic unit…
Q: What is RNAP II ?
A: Enzymes play an important role in several functions of the body. They are proteins that contain a…
Q: What is TATA box–binding protein (TBP)?
A: To determine: To determine what is TATA box–binding protein (TBP) and its uses
Q: What are three similarities and three differences between Chromatin Remodeling and microRNAs?
A: Chromatin remodelling is basically chemical modification of the chromatin structure for uncoiling…
Q: what is the AT-rich promoter element located approximately 25-30 bases upstream of the transcription…
A: The promoter is a regulatory region of DNA located upstream (towards the 5' region), the binding…
Q: Please explain the critical role of TFIID in the initiation of eukaryotic transcription?
A: Initiation is the first step of eukaryotic transcription.For initiation it requires RNAP and…
Q: Why is it important for the transcription bubble to remain a constant size?
A: Transcription is the first step in gene expression, in which information from a gene is used to…
Q: Prokaryotes and lower eukaryotes such as yeast have transcription control elements called upstream…
A: Upstream activation sequences plays essential role in induction, enhancement and expression of gene…
Q: What structural change occurs in the DNA when an “open” transcription initiation complex is formed?
A: When an “open” transcription initiation complex is formed then this leads to the…
Q: What is the meaning of the term consensus sequence? Give an example. Describe the locations of…
A: The consensus sequences are widely used in molecular biology. The genes are controlled by the…
Q: Why does histone deacetylase action tend to repress transcription?
A: Transcription is the process of producing messenger RNA. This mRNA synthesizes proteins which is…
Q: List two different ways in which trans-acting small RNAs(sRNAs) regulate the expression of target…
A: Trans-acting small RNAs or ta-siRNA are a class of siRNA that is responsible for repressing gene…
Q: Why is transcription a particularly important level of gene regulation in both bacteria and…
A: Gene regulation is the process that is involved in turning on or off of a gene, which ensures that…
Q: Why is an NFR needed at the core promoter for transcription to occur?
A: DNA is the genetic material in most living organisms. It is the information hub of the cell that…
Q: What is miRNA replacement therapy? Describe three examples of this treatment approach.
A: A Gene is a unit of heredity containing the fundamental information of life as a distinct sequence…
Q: For RNA Plymerase type two generated transcripts in eukaryotes, how polyadenylation is linked with…
A: The poly-A tail makes the RNA molecule more stable and prevents its degradation. Additionally, the…
Q: With regard to RNAi, what are three possible sources for doublestrandedRNA?
A: Gene regulation involves the expression of certain genes at a time out of all the genes present in…
Q: What is the role of TFIID in transcription initiation?
A: The general transcription factor complex such as TFIID plays a major role in the initiation of…
Q: How dispersed promoters specify multiple transcriptional start sites ?
A: Answer:Introduction: In vertebrates, approximately 70% of genes contain dispersed promoters, that…
Q: What general transcription factors associate with an RNA polymerase II promoter in addition to the…
A: Transcription is the process of synthesis of mRNA from DNA. RNA polymerase is the enzyme which carry…
Q: Please explain the critical role of TFIID in the initiation of eucaryotic transcription?
A: TFIID (Transcription factor II D )is the first protein to bind to DNA during formation of…
Q: What are the essential components for the transcription control in prokaryotes? Please explain…
A: The expression of bacterial genes in prokaryotes are controlled mainly at the level of…
Q: How does the binding of transcriptional regulator proteins to enhancers affect transcription at…
A: Introduction Protein is the key biomolecule in the biological system, any important physiological…
Q: What would be the effect on transcription of a short insertional mutation between the-10 box and the…
A: The central dogma of molecular biology explains the flow of genetic information through the…
Q: What are some similarities and differences between siRNAs and miRNAs?
A: Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in decoding,…
Q: How is miRNA-206 beneficial to an organism?
A: miRNA-206 : A microRNA is a small single-stranded non-coding RNA molecule found in plants, animals…
What is a potential link between prostate cancer and miRNA-101?
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- . Why is a nonsense suppressor tRNATyr, even though ithas a mutant anticodon that cannot recognize a tyrosinecodon, charged with tyrosine by Tyr tRNA synthetase?What general transcription factors associate with an RNA polymerase II promoter in addition to the polymerase? In what order do they bind in vitro?What is the function of the repressor CI? What is its importance in protein biology?